General Information
Term	negative regulation of metabolic process	ID (Ontology)	GO:0009892 (Gene Ontology)
Definition	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
Also Known As	"down regulation of metabolic process" ; "down-regulation of metabolic process" ; "downregulation of metabolic process" (for all, see Synonyms field below)
Comment
Links to External Ontologies
	QuickGO data AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
No relevant records available
Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
No relevant statements available
metabolic process
 |__regulation of metabolic process__________
negative regulation of biological process    |
 |__negative regulation of cellular process__|
regulation of cellular process               |
 |__regulation of metabolic process__________|
 |__negative regulation of cellular process__|
                                             negative regulation of metabolic process  1055 rec.
                                              |__negative regulation of amide metabolic process 1 rec.
                                              |   |__negative regulation of amide catabolic process(+)
                                              |   |__negative regulation of amyloid-beta formation
                                              |   |__negative regulation of butyryl-CoA biosynthetic process from acetyl-CoA
                                              |   |__negative regulation of butyryl-CoA catabolic process to butanol
                                              |   |__negative regulation of butyryl-CoA catabolic process to butyrate
                                              |   |__negative regulation of ceramide biosynthetic process(+)
                                              |   |__negative regulation of emericellamide biosynthetic process(+)
                                              |   |__negative regulation of ferrichrome biosynthetic process(+)
                                              |   |__negative regulation of gliotoxin biosynthetic process
                                              |   |__negative regulation of glutathione biosynthetic process
                                              |   |__negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
                                              |   |__negative regulation of penicillin biosynthetic process
                                              |   |__negative regulation of penicillin catabolic process
                                              |   |__negative regulation of peptide hormone processing 1 rec.
                                              |   |__negative regulation of pseurotin A biosynthetic process
                                              |   |__negative regulation of pyruvate decarboxylation to acetyl-CoA
                                              |   |__negative regulation of tensidol A biosynthetic process
                                              |   |__negative regulation of tensidol B biosynthetic process
                                              |   |__negative regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
                                              |__negative regulation of amine metabolic process 1 rec.
                                              |   |__negative regulation of amine catabolic process(+)
                                              |   |__negative regulation of dopamine metabolic process(+) 1 rec.
                                              |   |__negative regulation of methane biosynthetic process from dimethylamine
                                              |   |__negative regulation of methane biosynthetic process from methylamine
                                              |   |__negative regulation of methane biosynthetic process from trimethylamine
                                              |   |__negative regulation of polyamine biosynthetic process(+)
                                              |__negative regulation of amino acid metabolic process
                                              |   |__negative regulation of 'de novo' NAD biosynthetic process from L-tryptophan
                                              |   |__negative regulation of amino acid biosynthetic process(+)
                                              |   |__negative regulation of arginine catabolic process
                                              |   |__negative regulation of gamma-aminobutyric acid catabolic process
                                              |   |__negative regulation of glutamate metabolic process(+)
                                              |   |__negative regulation of indoleacetic acid biosynthetic process via tryptophan
                                              |   |__negative regulation of ornithine catabolic process
                                              |   |__negative regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
                                              |__negative regulation of anthocyanin metabolic process
                                              |   |__negative regulation of anthocyanin biosynthetic process
                                              |   |__negative regulation of anthocyanin catabolic process
                                              |__negative regulation of bioluminescence
                                              |__negative regulation of biosynthetic process 943 rec.
                                              |   |__negative regulation of (R)-mevalonic acid biosynthetic process
                                              |   |__negative regulation of acetylcholine biosynthetic process
                                              |   |__negative regulation of alcohol biosynthetic process(+)
                                              |   |__negative regulation of alkane biosynthetic process(+)
                                              |   |__negative regulation of amino acid biosynthetic process(+)
                                              |   |__negative regulation of austinol biosynthetic process
                                              |   |__negative regulation of collagen biosynthetic process
                                              |   |__negative regulation of dopamine biosynthetic process
                                              |   |__negative regulation of flavonoid biosynthetic process(+)
                                              |   |__negative regulation of fumagillin biosynthetic process
                                              |   |__negative regulation of gluconeogenesis
                                              |   |__negative regulation of glutathione biosynthetic process
                                              |   |__negative regulation of hexadecanal biosynthetic process
                                              |   |__negative regulation of hormone biosynthetic process(+) 4 rec.
                                              |   |__negative regulation of hydrogen sulfide biosynthetic process
                                              |   |__negative regulation of L-ascorbic acid biosynthetic process
                                              |   |__negative regulation of lactose biosynthetic process
                                              |   |__negative regulation of lipid biosynthetic process(+) 6 rec.
                                              |   |__negative regulation of macromolecule biosynthetic process(+) 929 rec.
                                              |   |__negative regulation of methanofuran biosynthetic process
                                              |   |__negative regulation of methanophenazine biosynthetic process
                                              |   |__negative regulation of naphtho-gamma-pyrone biosynthetic process
                                              |   |__negative regulation of nitric oxide biosynthetic process
                                              |   |__negative regulation of nucleotide biosynthetic process(+)
                                              |   |__negative regulation of olefin biosynthetic process(+)
                                              |   |__negative regulation of phenazine biosynthetic process
                                              |   |__negative regulation of polyamine biosynthetic process(+)
                                              |   |__negative regulation of pseurotin A biosynthetic process
                                              |   |__negative regulation of pyruvate decarboxylation to acetyl-CoA
                                              |   |__negative regulation of quinolinate biosynthetic process
                                              |   |__negative regulation of raffinose biosynthetic process
                                              |   |__negative regulation of reactive oxygen species biosynthetic process(+) 3 rec.
                                              |   |__negative regulation of reductive pentose-phosphate cycle
                                              |   |__negative regulation of sarcinapterin biosynthetic process
                                              |   |__negative regulation of secondary metabolite biosynthetic process(+) 1 rec.
                                              |   |__negative regulation of serotonin biosynthetic process
                                              |   |__negative regulation of tatiopterin biosynthetic process
                                              |   |__negative regulation of tetrapyrrole biosynthetic process(+)
                                              |   |__negative regulation of thiamine diphosphate biosynthetic process
                                              |   |__negative regulation of trypanothione biosynthetic process
                                              |   |__negative regulation of ubiquinone biosynthetic process
                                              |   |__negative regulation of UDP-N-acetylglucosamine biosynthetic process 1 rec.
                                              |   |__negative regulation of xanthone-containing compound biosynthetic process(+)
                                              |__negative regulation of carbohydrate metabolic process 5 rec.
                                              |   |__negative regulation of (1->3)-beta-D-glucan biosynthetic process
                                              |   |__negative regulation of cell wall polysaccharide catabolic process(+)
                                              |   |__negative regulation of cellobiose catabolic process
                                              |   |__negative regulation of cellodextrin catabolic process
                                              |   |__negative regulation of cellooligosaccharide catabolic process
                                              |   |__negative regulation of cellotriose catabolic process
                                              |   |__negative regulation of cellulose biosynthetic process(+)
                                              |   |__negative regulation of cellulose catabolic process
                                              |   |__negative regulation of cyclodextrin catabolic process
                                              |   |__negative regulation of galactoglucomannan catabolic process
                                              |   |__negative regulation of galactomannan catabolic process
                                              |   |__negative regulation of glucomannan catabolic process
                                              |   |__negative regulation of gluconeogenesis
                                              |   |__negative regulation of glucose catabolic process to lactate via pyruvate
                                              |   |__negative regulation of glycogen metabolic process(+) 4 rec.
                                              |   |__negative regulation of glycolytic fermentation to ethanol
                                              |   |__negative regulation of glycolytic process(+) 1 rec.
                                              |   |__negative regulation of glyoxylate cycle
                                              |   |__negative regulation of hemicellulose catabolic process(+)
                                              |   |__negative regulation of hyaluronan biosynthetic process
                                              |   |__negative regulation of inositol phosphate biosynthetic process(+)
                                              |   |__negative regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
                                              |   |__negative regulation of L-ascorbic acid biosynthetic process
                                              |   |__negative regulation of lactose biosynthetic process
                                              |   |__negative regulation of pectin catabolic process
                                              |   |__negative regulation of raffinose biosynthetic process
                                              |   |__negative regulation of reductive pentose-phosphate cycle
                                              |   |__negative regulation of starch biosynthetic process
                                              |   |__negative regulation of starch catabolic process(+)
                                              |   |__negative regulation of xylose catabolic process to ethanol
                                              |__negative regulation of catabolic process 78 rec.
                                              |   |__negative regulation of acetate catabolic process
                                              |   |__negative regulation of alcohol catabolic process
                                              |   |__negative regulation of amide catabolic process(+)
                                              |   |__negative regulation of amine catabolic process(+)
                                              |   |__negative regulation of anthocyanin catabolic process
                                              |   |__negative regulation of autophagy(+) 31 rec.
                                              |   |__negative regulation of cell wall polysaccharide catabolic process(+)
                                              |   |__negative regulation of cellobiose catabolic process
                                              |   |__negative regulation of cellodextrin catabolic process
                                              |   |__negative regulation of cellooligosaccharide catabolic process
                                              |   |__negative regulation of cellotriose catabolic process
                                              |   |__negative regulation of cellulose catabolic process
                                              |   |__negative regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process
                                              |   |__negative regulation of collagen catabolic process
                                              |   |__negative regulation of cyclodextrin catabolic process
                                              |   |__negative regulation of DNA catabolic process(+)
                                              |   |__negative regulation of ferulate catabolic process
                                              |   |__negative regulation of galactoglucomannan catabolic process
                                              |   |__negative regulation of galactomannan catabolic process
                                              |   |__negative regulation of gamma-aminobutyric acid catabolic process
                                              |   |__negative regulation of glucomannan catabolic process
                                              |   |__negative regulation of glucose catabolic process to lactate via pyruvate
                                              |   |__negative regulation of glycogen catabolic process 3 rec.
                                              |   |__negative regulation of glycolytic fermentation to ethanol
                                              |   |__negative regulation of hemicellulose catabolic process(+)
                                              |   |__negative regulation of hydrogen peroxide catabolic process
                                              |   |__negative regulation of L-proline catabolic process to L-glutamate
                                              |   |__negative regulation of lipid catabolic process(+) 8 rec.
                                              |   |__negative regulation of nucleotide catabolic process(+) 1 rec.
                                              |   |__negative regulation of ornithine catabolic process
                                              |   |__negative regulation of pectin catabolic process
                                              |   |__negative regulation of penicillin catabolic process
                                              |   |__negative regulation of protein catabolic process(+) 18 rec.
                                              |   |__negative regulation of receptor catabolic process(+)
                                              |   |__negative regulation of RNA catabolic process(+) 14 rec.
                                              |   |__negative regulation of starch catabolic process(+)
                                              |   |__negative regulation of syringal lignin catabolic process
                                              |   |__negative regulation of tetrapyrrole catabolic process(+)
                                              |   |__negative regulation of toluene catabolic process
                                              |   |__negative regulation of ubiquitin-dependent protein catabolic process(+) 16 rec.
                                              |   |__negative regulation of xylose catabolic process to ethanol
                                              |__negative regulation of cellular respiration 2 rec.
                                              |   |__negative regulation of methane biosynthetic process from 3-(methylthio)propionic acid
                                              |   |__negative regulation of methane biosynthetic process from carbon monoxide
                                              |   |__negative regulation of methane biosynthetic process from dimethyl sulfide
                                              |   |__negative regulation of methane biosynthetic process from dimethylamine
                                              |   |__negative regulation of methane biosynthetic process from formic acid
                                              |   |__negative regulation of methane biosynthetic process from methanethiol
                                              |   |__negative regulation of methane biosynthetic process from methylamine
                                              |   |__negative regulation of methane biosynthetic process from trimethylamine
                                              |   |__negative regulation of oxidative phosphorylation(+) 2 rec.
                                              |__negative regulation of cobalamin metabolic process
                                              |__negative regulation of cold-induced thermogenesis
                                              |__negative regulation of collagen metabolic process
                                              |   |__negative regulation of collagen biosynthetic process
                                              |   |__negative regulation of collagen catabolic process
                                              |__negative regulation of fermentation
                                              |   |__negative regulation of glucose catabolic process to lactate via pyruvate
                                              |   |__negative regulation of xylose catabolic process to ethanol
                                              |__negative regulation of hormone metabolic process 6 rec.
                                              |   |__negative regulation of auxin metabolic process(+)
                                              |   |__negative regulation of hormone biosynthetic process(+) 4 rec.
                                              |   |__negative regulation of juvenile hormone metabolic process(+) 4 rec.
                                              |   |__negative regulation of peptide hormone processing 1 rec.
                                              |   |__negative regulation of retinoic acid biosynthetic process
                                              |   |__negative regulation of thyroid hormone generation
                                              |__negative regulation of lipid metabolic process 15 rec.
                                              |   |__negative regulation of fatty acid metabolic process(+) 2 rec.
                                              |   |__negative regulation of isoprenoid metabolic process(+) 4 rec.
                                              |   |__negative regulation of lipid biosynthetic process(+) 6 rec.
                                              |   |__negative regulation of lipid catabolic process(+) 8 rec.
                                              |   |__negative regulation of lipoprotein lipid oxidation
                                              |   |__negative regulation of phospholipid metabolic process(+)
                                              |   |__negative regulation of steroid metabolic process(+)
                                              |   |__negative regulation of triglyceride metabolic process(+) 5 rec.
                                              |__negative regulation of macromolecule metabolic process 1000 rec.
                                              |   |__negative regulation of cell wall polysaccharide catabolic process(+)
                                              |   |__negative regulation of cellodextrin catabolic process
                                              |   |__negative regulation of cellulose catabolic process
                                              |   |__negative regulation of cyclodextrin catabolic process
                                              |   |__negative regulation of DNA metabolic process(+) 44 rec.
                                              |   |__negative regulation of galactoglucomannan catabolic process
                                              |   |__negative regulation of galactomannan catabolic process
                                              |   |__negative regulation of glucomannan catabolic process
                                              |   |__negative regulation of glycogen metabolic process(+) 4 rec.
                                              |   |__negative regulation of hemicellulose catabolic process(+)
                                              |   |__negative regulation of macromolecule biosynthetic process(+) 929 rec.
                                              |   |__negative regulation of pectin catabolic process
                                              |   |__negative regulation of protein metabolic process(+) 140 rec.
                                              |   |__negative regulation of receptor catabolic process(+)
                                              |   |__negative regulation of receptor recycling 3 rec.
                                              |   |__negative regulation of RNA metabolic process(+) 340 rec.
                                              |   |__negative regulation of starch catabolic process(+)
                                              |__negative regulation of melanization defense response 5 rec.
                                              |   |__negative regulation melanotic encapsulation of foreign target 3 rec.
                                              |__negative regulation of metabolic activity involved in hibernation
                                              |__negative regulation of nitrogen cycle metabolic process
                                              |   |__negative regulation of urea catabolic process
                                              |__negative regulation of nucleobase-containing compound metabolic process 383 rec.
                                              |   |__negative regulation of butyryl-CoA biosynthetic process from acetyl-CoA
                                              |   |__negative regulation of butyryl-CoA catabolic process to butanol
                                              |   |__negative regulation of butyryl-CoA catabolic process to butyrate
                                              |   |__negative regulation of DNA metabolic process(+) 44 rec.
                                              |   |__negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
                                              |   |__negative regulation of nucleoside metabolic process
                                              |   |__negative regulation of nucleotide metabolic process(+) 1 rec.
                                              |   |__negative regulation of purine nucleobase metabolic process
                                              |   |__negative regulation of pyrimidine nucleobase metabolic process
                                              |   |__negative regulation of pyruvate decarboxylation to acetyl-CoA
                                              |   |__negative regulation of RNA metabolic process(+) 340 rec.
                                              |   |__negative regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
                                              |   |__negative regulation of UDP-N-acetylglucosamine biosynthetic process 1 rec.
                                              |__negative regulation of organofluorine metabolic process
                                              |__negative regulation of phosphorus metabolic process 3 rec.
                                              |   |__negative regulation of phosphate metabolic process(+) 3 rec.
                                              |   |__negative regulation of phosphorus utilization
                                              |   |__negative regulation of tatiopterin biosynthetic process
                                              |__negative regulation of photosynthesis
                                              |   |__negative regulation of photosynthesis, light reaction(+)
                                              |   |__negative regulation of reductive pentose-phosphate cycle
                                              |__negative regulation of reactive oxygen species metabolic process 7 rec.
                                              |   |__negative regulation of hydrogen peroxide metabolic process(+)
                                              |   |__negative regulation of reactive oxygen species biosynthetic process(+) 3 rec.
                                              |   |__negative regulation of removal of superoxide radicals 1 rec.
                                              |   |__negative regulation of superoxide anion generation
                                              |__negative regulation of respiratory burst
                                              |   |__negative regulation of respiratory burst involved in inflammatory response
                                              |__negative regulation of siRNA processing
                                              |__negative regulation of small molecule metabolic process 4 rec.
                                                  |__negative regulation of (R)-mevalonic acid biosynthetic process
                                                  |__negative regulation of acetate catabolic process
                                                  |__negative regulation of aflatoxin biosynthetic process
                                                  |__negative regulation of alcohol biosynthetic process(+)
                                                  |__negative regulation of alcohol catabolic process
                                                  |__negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
                                                  |__negative regulation of androst-4-ene-3,17-dione biosynthetic process
                                                  |__negative regulation of arginine catabolic process
                                                  |__negative regulation of asperthecin biosynthetic process
                                                  |__negative regulation of bile acid biosynthetic process
                                                  |__negative regulation of cholesterol metabolic process(+)
                                                  |__negative regulation of citrulline biosynthetic process
                                                  |__negative regulation of ecdysteroid biosynthetic process
                                                  |__negative regulation of emericellamide biosynthetic process(+)
                                                  |__negative regulation of emodin biosynthetic process
                                                  |__negative regulation of endocrocin biosynthetic process
                                                  |__negative regulation of fatty acid metabolic process(+) 2 rec.
                                                  |__negative regulation of ferulate catabolic process
                                                  |__negative regulation of fumagillin biosynthetic process
                                                  |__negative regulation of fumonisin biosynthetic process
                                                  |__negative regulation of gamma-aminobutyric acid catabolic process
                                                  |__negative regulation of gerfelin biosynthetic process
                                                  |__negative regulation of gibberellin biosynthetic process
                                                  |__negative regulation of gluconeogenesis
                                                  |__negative regulation of glucose catabolic process to lactate via pyruvate
                                                  |__negative regulation of glutamate metabolic process(+)
                                                  |__negative regulation of glycolytic fermentation to ethanol
                                                  |__negative regulation of glyoxylate cycle
                                                  |__negative regulation of helvolic acid biosynthetic process
                                                  |__negative regulation of histidine biosynthetic process
                                                  |__negative regulation of homoserine biosynthetic process
                                                  |__negative regulation of indoleacetic acid biosynthetic process via tryptophan
                                                  |__negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
                                                  |__negative regulation of L-dopa biosynthetic process
                                                  |__negative regulation of L-glutamine biosynthetic process
                                                  |__negative regulation of L-leucine biosynthetic process
                                                  |__negative regulation of L-proline biosynthetic process
                                                  |__negative regulation of lysine biosynthetic process via aminoadipic acid(+)
                                                  |__negative regulation of methane biosynthetic process from formic acid
                                                  |__negative regulation of monodictyphenone biosynthetic process
                                                  |__negative regulation of naphtho-gamma-pyrone biosynthetic process
                                                  |__negative regulation of nucleoside metabolic process
                                                  |__negative regulation of nucleotide metabolic process(+) 1 rec.
                                                  |__negative regulation of o-orsellinic acid biosynthetic process
                                                  |__negative regulation of ornithine catabolic process
                                                  |__negative regulation of penicillin biosynthetic process
                                                  |__negative regulation of penicillin catabolic process
                                                  |__negative regulation of progesterone biosynthetic process(+)
                                                  |__negative regulation of pseurotin A biosynthetic process
                                                  |__negative regulation of purine nucleobase metabolic process
                                                  |__negative regulation of pyrimidine nucleobase metabolic process
                                                  |__negative regulation of pyruvate decarboxylation to acetyl-CoA
                                                  |__negative regulation of quinolinate biosynthetic process
                                                  |__negative regulation of sarcinapterin biosynthetic process
                                                  |__negative regulation of tatiopterin biosynthetic process
                                                  |__negative regulation of tensidol A biosynthetic process
                                                  |__negative regulation of tensidol B biosynthetic process
                                                  |__negative regulation of testosterone biosynthetic process
                                                  |__negative regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
                                                  |__negative regulation of ubiquinone biosynthetic process
                                                  |__negative regulation of UDP-N-acetylglucosamine biosynthetic process 1 rec.
                                                  |__negative regulation of urea catabolic process
                                                  |__negative regulation of vitamin metabolic process(+)
                                                  |__negative regulation of xanthone-containing compound biosynthetic process(+)
                                                  |__negative regulation of xylose catabolic process to ethanol
Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	regulation of metabolic process negative regulation of cellular process
Part of
Synonyms & Secondary IDs
Synonyms
	"down regulation of metabolic process" EXACT "down-regulation of metabolic process" EXACT "downregulation of metabolic process" EXACT "inhibition of metabolic process" NARROW "inhibition of organismal metabolic process" NARROW "negative regulation of metabolism" EXACT "negative regulation of multicellular organismal metabolic process" NARROW "negative regulation of organismal metabolism" EXACT
Secondary IDs

External Crossreferences & Linkouts