FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term regulation of gene expression ID (Ontology) GO:0010468 (Gene Ontology)
Definition Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      90
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 regulation of gene expression (all annotations which use CV term, excluding "NOT" statements)      90
     involved_in | regulation of gene expression      90
Spanning Tree (Parents/Children)
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regulation of biosynthetic process_____________
regulation of macromolecule metabolic process__|
                                               regulation of macromolecule biosynthetic process
                                                |__regulation of gene expression  1988 rec.
                                                    |__circadian regulation of gene expression 8 rec.
                                                    |__epigenetic regulation of gene expression 255 rec.
                                                    |   |__epigenetic programming of gene expression(+) 2 rec.
                                                    |   |__negative regulation of gene expression, epigenetic(+) 217 rec.
                                                    |   |__positive regulation of gene expression, epigenetic(+) 14 rec.
                                                    |   |__sex-chromosome dosage compensation(+) 27 rec.
                                                    |__maternal-to-zygotic transition of gene expression 5 rec.
                                                    |__negative regulation of gene expression 660 rec.
                                                    |   |__mRNA catabolic process(+) 138 rec.
                                                    |   |__mRNA destabilization(+) 68 rec.
                                                    |   |__negative regulation of cytokine production(+) 2 rec.
                                                    |   |__negative regulation of gene expression, epigenetic(+) 217 rec.
                                                    |   |__negative regulation of miRNA processing(+) 3 rec.
                                                    |   |__negative regulation of oxytocin production
                                                    |   |__negative regulation of production of molecular mediator of immune response(+) 20 rec.
                                                    |   |__negative regulation of protein maturation(+) 6 rec.
                                                    |   |__negative regulation of RNA splicing(+) 8 rec.
                                                    |   |__negative regulation of rRNA processing
                                                    |   |__negative regulation of snoRNA processing
                                                    |   |__negative regulation of translation(+) 85 rec.
                                                    |   |__negative regulation of tRNA processing
                                                    |   |__post-transcriptional gene silencing(+) 211 rec.
                                                    |   |__programmed DNA elimination(+)
                                                    |   |__regulatory ncRNA-mediated gene silencing(+) 263 rec.
                                                    |   |__transcriptional attenuation(+)
                                                    |   |__transposable element silencing(+) 45 rec.
                                                    |__negative regulation of transcription initiation-coupled chromatin remodeling
                                                    |__positive regulation of gene expression 224 rec.
                                                    |   |__negative regulation of gene silencing by regulatory ncRNA(+) 10 rec.
                                                    |   |__negative regulation of heterochromatin formation(+) 9 rec.
                                                    |   |__negative regulation of mRNA catabolic process(+) 11 rec.
                                                    |   |__negative regulation of post-transcriptional gene silencing(+) 9 rec.
                                                    |   |__positive regulation of 3'-UTR-mediated mRNA stabilization 1 rec.
                                                    |   |__positive regulation of cytokine production(+) 3 rec.
                                                    |   |__positive regulation of gene expression, epigenetic(+) 14 rec.
                                                    |   |__positive regulation of miRNA processing(+)
                                                    |   |__positive regulation of oxytocin production
                                                    |   |__positive regulation of production of molecular mediator of immune response(+) 61 rec.
                                                    |   |__positive regulation of protein maturation(+) 2 rec.
                                                    |   |__positive regulation of RNA splicing(+) 6 rec.
                                                    |   |__positive regulation of snoRNA processing
                                                    |   |__positive regulation of translation(+) 47 rec.
                                                    |   |__positive regulation of tRNA processing(+) 1 rec.
                                                    |   |__transcription antitermination
                                                    |   |__zygotic genome activation
                                                    |__post-transcriptional regulation of gene expression 389 rec.
                                                    |   |__mRNA localization resulting in post-transcriptional regulation of gene expression
                                                    |   |__post-transcriptional gene silencing(+) 211 rec.
                                                    |   |__regulation of RNA stability(+) 89 rec.
                                                    |   |__regulation of translation(+) 169 rec.
                                                    |__pre-B cell allelic exclusion
                                                    |__regulation of cytokine production 5 rec.
                                                    |   |__negative regulation of cytokine production(+) 2 rec.
                                                    |   |__positive regulation of cytokine production(+) 3 rec.
                                                    |   |__regulation of amphiregulin production(+)
                                                    |   |__regulation of chemokine production(+)
                                                    |   |__regulation of connective tissue growth factor production(+)
                                                    |   |__regulation of cytokine production involved in immune response(+) 1 rec.
                                                    |   |__regulation of cytokine production involved in inflammatory response(+)
                                                    |   |__regulation of endothelin production(+)
                                                    |   |__regulation of fibroblast growth factor production(+)
                                                    |   |__regulation of glial cell-derived neurotrophic factor production(+)
                                                    |   |__regulation of granulocyte macrophage colony-stimulating factor production(+)
                                                    |   |__regulation of granzyme B production(+)
                                                    |   |__regulation of hepatocyte growth factor production(+)
                                                    |   |__regulation of interleukin-1 production(+)
                                                    |   |__regulation of interleukin-2 production(+)
                                                    |   |__regulation of interleukin-3 production(+)
                                                    |   |__regulation of interleukin-4 production(+)
                                                    |   |__regulation of interleukin-5 production(+)
                                                    |   |__regulation of interleukin-6 production(+)
                                                    |   |__regulation of interleukin-7 production(+)
                                                    |   |__regulation of interleukin-8 production(+)
                                                    |   |__regulation of interleukin-9 production(+)
                                                    |   |__regulation of interleukin-10 production(+)
                                                    |   |__regulation of interleukin-11 production(+)
                                                    |   |__regulation of interleukin-12 production(+)
                                                    |   |__regulation of interleukin-13 production(+)
                                                    |   |__regulation of interleukin-15 production(+)
                                                    |   |__regulation of interleukin-16 production(+)
                                                    |   |__regulation of interleukin-17 production(+)
                                                    |   |__regulation of interleukin-18 production(+)
                                                    |   |__regulation of interleukin-19 production(+)
                                                    |   |__regulation of interleukin-20 production(+)
                                                    |   |__regulation of interleukin-21 production(+)
                                                    |   |__regulation of interleukin-22 production(+)
                                                    |   |__regulation of interleukin-23 production(+)
                                                    |   |__regulation of interleukin-24 production(+)
                                                    |   |__regulation of interleukin-25 production(+)
                                                    |   |__regulation of interleukin-26 production(+)
                                                    |   |__regulation of interleukin-27 production(+)
                                                    |   |__regulation of interleukin-32 production(+)
                                                    |   |__regulation of interleukin-33 production(+)
                                                    |   |__regulation of interleukin-34 production(+)
                                                    |   |__regulation of interleukin-35 production(+)
                                                    |   |__regulation of interleukin-37 production(+)
                                                    |   |__regulation of macrophage colony-stimulating factor production(+)
                                                    |   |__regulation of platelet-derived growth factor production(+)
                                                    |   |__regulation of transforming growth factor beta production(+)
                                                    |   |__regulation of tumor necrosis factor superfamily cytokine production(+)
                                                    |   |__regulation of type I interferon production(+) 2 rec.
                                                    |   |__regulation of type II interferon production(+)
                                                    |   |__regulation of type III interferon production(+)
                                                    |   |__regulation of vascular endothelial growth factor production(+) 1 rec.
                                                    |__regulation of DNA-templated transcription 1176 rec.
                                                    |   |__carbon catabolite regulation of transcription(+)
                                                    |   |__negative regulation of DNA-templated transcription(+) 322 rec.
                                                    |   |__nitrogen catabolite regulation of transcription(+)
                                                    |   |__positive regulation of DNA-templated transcription(+) 449 rec.
                                                    |   |__regulation of antisense RNA transcription(+)
                                                    |   |__regulation of DNA-binding transcription factor activity(+) 1 rec.
                                                    |   |__regulation of DNA-templated transcription elongation(+) 39 rec.
                                                    |   |__regulation of DNA-templated transcription initiation(+) 19 rec.
                                                    |   |__regulation of lncRNA transcription(+)
                                                    |   |__regulation of mating-type specific transcription, DNA-templated(+)
                                                    |   |__regulation of miRNA transcription(+)
                                                    |   |__regulation of mitochondrial transcription(+) 4 rec.
                                                    |   |__regulation of piRNA transcription(+) 10 rec.
                                                    |   |__regulation of transcription by galactose(+)
                                                    |   |__regulation of transcription by glucose(+) 1 rec.
                                                    |   |__regulation of transcription by RNA polymerase I(+) 10 rec.
                                                    |   |__regulation of transcription by RNA polymerase II(+) 888 rec.
                                                    |   |__regulation of transcription by RNA polymerase III(+) 6 rec.
                                                    |   |__regulation of transcription by RNA polymerase V(+)
                                                    |__regulation of gene silencing by regulatory ncRNA 17 rec.
                                                    |   |__negative regulation of gene silencing by regulatory ncRNA(+) 10 rec.
                                                    |   |__regulation of post-transcriptional gene silencing by regulatory ncRNA(+) 12 rec.
                                                    |   |__regulation of regulatory ncRNA processing(+) 7 rec.
                                                    |   |__regulation of regulatory ncRNA-mediated heterochromatin formation(+) 1 rec.
                                                    |__regulation of heterochromatin formation 22 rec.
                                                    |   |__negative regulation of heterochromatin formation(+) 9 rec.
                                                    |   |__positive regulation of heterochromatin formation(+) 11 rec.
                                                    |   |__regulation of pericentric heterochromatin formation(+) 2 rec.
                                                    |   |__regulation of rDNA heterochromatin formation(+)
                                                    |   |__regulation of regulatory ncRNA-mediated heterochromatin formation(+) 1 rec.
                                                    |   |__regulation of silent mating-type cassette heterochromatin formation(+)
                                                    |   |__regulation of siRNA-independent facultative heterochromatin formation
                                                    |__regulation of mitochondrial gene expression 14 rec.
                                                    |   |__regulation of mitochondrial transcription(+) 4 rec.
                                                    |   |__regulation of mitochondrial translation(+) 9 rec.
                                                    |__regulation of mRNA catabolic process 87 rec.
                                                    |   |__negative regulation of mRNA catabolic process(+) 11 rec.
                                                    |   |__positive regulation of mRNA catabolic process(+) 69 rec.
                                                    |   |__regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA(+)
                                                    |   |__regulation of mitochondrial mRNA catabolic process(+) 2 rec.
                                                    |   |__regulation of mRNA stability(+) 84 rec.
                                                    |   |__regulation of nuclear mRNA surveillance of meiosis-specific transcripts(+)
                                                    |   |__regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(+) 1 rec.
                                                    |   |__regulation of nuclear-transcribed mRNA poly(A) tail shortening(+) 6 rec.
                                                    |__regulation of oxytocin production
                                                    |   |__negative regulation of oxytocin production
                                                    |   |__positive regulation of oxytocin production
                                                    |__regulation of post-transcriptional gene silencing 14 rec.
                                                    |   |__negative regulation of post-transcriptional gene silencing(+) 9 rec.
                                                    |   |__positive regulation of post-transcriptional gene silencing(+) 3 rec.
                                                    |   |__regulation of post-transcriptional gene silencing by regulatory ncRNA(+) 12 rec.
                                                    |__regulation of production of molecular mediator of immune response 84 rec.
                                                    |   |__negative regulation of production of molecular mediator of immune response(+) 20 rec.
                                                    |   |__positive regulation of production of molecular mediator of immune response(+) 61 rec.
                                                    |   |__regulation of antimicrobial peptide production(+) 83 rec.
                                                    |   |__regulation of cytokine production involved in immune response(+) 1 rec.
                                                    |   |__regulation of granzyme A production(+)
                                                    |   |__regulation of granzyme B production(+)
                                                    |   |__regulation of immunoglobulin production(+)
                                                    |__regulation of protein maturation 10 rec.
                                                    |   |__negative regulation of protein maturation(+) 6 rec.
                                                    |   |__positive regulation of protein maturation(+) 2 rec.
                                                    |   |__regulation of N-terminal peptidyl-lysine acetylation(+)
                                                    |   |__regulation of N-terminal peptidyl-methionine acetylation(+)
                                                    |   |__regulation of protein activation cascade(+) 5 rec.
                                                    |   |__regulation of protein processing(+) 5 rec.
                                                    |__regulation of RNA splicing 111 rec.
                                                    |   |__negative regulation of RNA splicing(+) 8 rec.
                                                    |   |__positive regulation of RNA splicing(+) 6 rec.
                                                    |   |__regulation of mRNA splicing, via spliceosome(+) 98 rec.
                                                    |__regulation of rRNA processing 2 rec.
                                                    |   |__negative regulation of rRNA processing
                                                    |   |__positive regulation of rRNA processing 2 rec.
                                                    |__regulation of snoRNA processing
                                                    |   |__negative regulation of snoRNA processing
                                                    |   |__positive regulation of snoRNA processing
                                                    |__regulation of tRNA processing 1 rec.
                                                        |__negative regulation of tRNA processing
                                                        |__positive regulation of tRNA processing(+) 1 rec.
                                                        |__regulation of tRNA methylation(+)
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Is a regulation of macromolecule biosynthetic process
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Synonyms
  • "gene regulation" RELATED
    "regulation of gene product expression" RELATED
    "regulation of protein expression" NARROW
Secondary IDs
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Reactome:R-HSA-163767 "PP2A-mediated dephosphorylation of key metabolic factors"
Reactome:R-HSA-9752946 "Expression and translocation of olfactory receptors"
Wikipedia:Regulation_of_gene_expression