FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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Term nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway ID (Ontology) GO:0035872 (Gene Ontology)
Definition The series of molecular signals initiated by a ligand binding to a nucleotide-binding domain, leucine rich repeat containing receptor (NLR), and ending with the regulation of a downstream cellular process. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number.[ PubMed:18280719 PubMed:32838963 PubMed:36973360 ]
Also Known As "NLR signaling pathway" ; "nucleotide-binding domain leucine-rich repeat containing receptor signaling pathway" ; "nucleotide-binding domain, leucine rich repeat containing receptor signal transduction" (for all, see Synonyms field below)
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pattern recognition receptor signaling pathway__
intracellular receptor signaling pathway________|
                                                cytoplasmic pattern recognition receptor signaling pathway
                                                 |__nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
                                                     |__nucleotide-binding oligomerization domain containing 1 signaling pathway
                                                     |   |__regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(+)
                                                     |__nucleotide-binding oligomerization domain containing 2 signaling pathway
                                                     |   |__regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(+)
                                                     |__regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
                                                         |__negative regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway(+)
                                                         |__positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway(+)
                                                         |__regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(+)
                                                         |__regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(+)
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Is a cytoplasmic pattern recognition receptor signaling pathway
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Synonyms
  • "NLR signaling pathway" EXACT[ PubMed:18280719 ]
    "NOD-like receptor signaling pathway" RELATED
    "nucleotide-binding domain leucine-rich repeat containing receptor signaling pathway" EXACT[ PubMed:18280719 ]
    "nucleotide-binding domain, leucine rich repeat containing receptor signal transduction" EXACT
    "nucleotide-binding domain, leucine rich repeat containing receptor signal transduction pathway" EXACT
    "nucleotide-binding domain, leucine rich repeat containing receptor signalling pathway" EXACT
Secondary IDs
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Reactome:R-HSA-168643 "Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways"