FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term non-canonical NF-kappaB signal transduction ID (Ontology) GO:0038061 (Gene Ontology)
Definition An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF).[ PubMed:11239468 PubMed:15140882 PubMed:34659217 ]
Also Known As "NIK-IKK kinase cascade" ; "NIK-IKK signaling pathway" ; "NIK-IKK-alpha cascade" (for all, see Synonyms field below)
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       2
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 non-canonical NF-kappaB signal transduction (all annotations which use CV term, excluding "NOT" statements)       2
     involved_in | non-canonical NF-kappaB signal transduction       2
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  intracellular signal transduction
   |__intracellular signaling cassette
       |__non-canonical NF-kappaB signal transduction  3 rec.
           |__activation of NF-kappaB-inducing kinase activity
           |__regulation of non-canonical NF-kappaB signal transduction 1 rec.
               |__negative regulation of non-canonical NF-kappaB signal transduction
               |__positive regulation of non-canonical NF-kappaB signal transduction 1 rec.
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Is a intracellular signaling cassette
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Reactome:R-HSA-5676590 "NIK-->noncanonical NF-kB signaling"