FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of cell cycle ID (Ontology) GO:0045786 (Gene Ontology)
Definition Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
Also Known As "down regulation of progression through cell cycle" ; "down-regulation of progression through cell cycle" ; "downregulation of progression through cell cycle" (for all, see Synonyms field below)
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       4
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 Genes
 negative regulation of cell cycle (all annotations which use CV term, excluding "NOT" statements)       4
     involved_in | negative regulation of cell cycle       4
Spanning Tree (Parents/Children)
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cell cycle
 |__regulation of cell cycle_________________
negative regulation of biological process    |
 |__negative regulation of cellular process__|
regulation of cellular process               |
 |__negative regulation of cellular process__|
 |__regulation of cell cycle_________________|
                                             negative regulation of cell cycle  97 rec.
                                              |__negative regulation of cell cycle process 90 rec.
                                              |   |__negative regulation of ascospore formation
                                              |   |__negative regulation of astral microtubule depolymerization
                                              |   |__negative regulation of cell cycle phase transition(+) 82 rec.
                                              |   |__negative regulation of cell cycle switching, mitotic to meiotic cell cycle
                                              |   |__negative regulation of centriole elongation 1 rec.
                                              |   |__negative regulation of centriole-centriole cohesion
                                              |   |__negative regulation of centrosome cycle(+) 1 rec.
                                              |   |__negative regulation of chromosome attachment to the nuclear envelope
                                              |   |__negative regulation of chromosome segregation(+) 14 rec.
                                              |   |__negative regulation of cytokinesis(+) 1 rec.
                                              |   |__negative regulation of DNA endoreduplication 2 rec.
                                              |   |__negative regulation of G0 to G1 transition
                                              |   |__negative regulation of G1 to G0 transition
                                              |   |__negative regulation of meiotic cell cycle process involved in oocyte maturation
                                              |   |__negative regulation of meiotic DNA double-strand break formation(+)
                                              |   |__negative regulation of meiotic joint molecule formation
                                              |   |__negative regulation of meiotic nuclear division(+) 4 rec.
                                              |   |__negative regulation of mitotic centrosome separation
                                              |   |__negative regulation of mitotic chromosome condensation
                                              |   |__negative regulation of mitotic DNA damage checkpoint
                                              |   |__negative regulation of mitotic nuclear division(+) 16 rec.
                                              |   |__negative regulation of mitotic nuclear envelope disassembly
                                              |   |__negative regulation of mitotic recombination-dependent replication fork processing
                                              |   |__negative regulation of mitotic spindle assembly checkpoint signaling(+)
                                              |   |__negative regulation of mitotic spindle elongation(+)
                                              |   |__negative regulation of mitotic spindle pole body separation
                                              |   |__negative regulation of nuclear cell cycle DNA replication(+)
                                              |   |__negative regulation of oocyte karyosome formation
                                              |   |__negative regulation of replicative senescence
                                              |   |__negative regulation of sister chromatid cohesion(+)
                                              |   |__negative regulation of spindle assembly(+)
                                              |   |__negative regulation of telomere maintenance via semi-conservative replication
                                              |__negative regulation of cyclin-dependent protein serine/threonine kinase activity
                                              |__negative regulation of meiotic cell cycle 7 rec.
                                              |   |__negative regulation of initiation of premeiotic DNA replication
                                              |   |__negative regulation of meiotic cell cycle phase transition(+) 3 rec.
                                              |   |__negative regulation of meiotic cell cycle process involved in oocyte maturation
                                              |   |__negative regulation of meiotic nuclear division(+) 4 rec.
                                              |   |__negative regulation of sexual sporulation resulting in formation of a cellular spore(+)
                                              |__negative regulation of mitotic cell cycle 69 rec.
                                                  |__cell cycle switching, mitotic to meiotic cell cycle(+) 4 rec.
                                                  |__mitotic cell cycle checkpoint signaling(+) 45 rec.
                                                  |__mitotic cell cycle G1 arrest in response to pheromone
                                                  |__negative regulation of mitotic cell cycle DNA replication(+)
                                                  |__negative regulation of mitotic cell cycle phase transition(+) 55 rec.
                                                  |__negative regulation of mitotic cell cycle, embryonic(+)
                                                  |__negative regulation of mitotic nuclear division(+) 16 rec.
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Is a negative regulation of cellular process
regulation of cell cycle
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Synonyms
  • "down regulation of progression through cell cycle" EXACT
    "down-regulation of progression through cell cycle" EXACT
    "downregulation of progression through cell cycle" EXACT
    "inhibition of progression through cell cycle" NARROW
    "negative regulation of cell cycle progression" EXACT
    "negative regulation of progression through cell cycle" EXACT
Secondary IDs
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Reactome:R-HSA-193670 "p75NTR negatively regulates cell cycle via SC1"