General Information
Term	leukocyte tethering or rolling	ID (Ontology)	GO:0050901 (Gene Ontology)
Definition	Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).[ ISBN:0781735149 PubMed:14680625 PubMed:14708592 PubMed:7507411 PubMed:8600538 ]
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General Information

Term

leukocyte tethering or rolling

ID (Ontology)

GO:0050901 (Gene Ontology)

Definition

Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).[ ISBN:0781735149 PubMed:14680625 PubMed:14708592 PubMed:7507411 PubMed:8600538 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

leukocyte cell-cell adhesion
 |__leukocyte adhesion to vascular endothelial cell__
leukocyte migration                                  |
 |__cellular extravasation___________________________|
                                                     leukocyte tethering or rolling
                                                      |__regulation of leukocyte tethering or rolling
                                                          |__negative regulation of leukocyte tethering or rolling
                                                          |__positive regulation of leukocyte tethering or rolling

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Is a	leukocyte adhesion to vascular endothelial cell
Part of	cellular extravasation
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Synonyms

Secondary IDs

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Is a

leukocyte adhesion to vascular endothelial cell

Part of

cellular extravasation

Synonyms & Secondary IDs

Synonyms

Secondary IDs

External Crossreferences & Linkouts