FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term mRNA destabilization ID (Ontology) GO:0061157 (Gene Ontology)
Definition Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       2
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 mRNA destabilization (all annotations which use CV term, excluding "NOT" statements)       2
     involved_in | mRNA destabilization       2
Spanning Tree (Parents/Children)
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positive regulation of catabolic process
 |__RNA destabilization____________________________________
 |__positive regulation of mRNA catabolic process__________|
regulation of gene expression                              |
 |__negative regulation of gene expression_________________|
negative regulation of macromolecule biosynthetic process  |
 |__negative regulation of gene expression_________________|
regulation of RNA stability                                |
 |__regulation of mRNA stability___________________________|
 |__RNA destabilization____________________________________|
positive regulation of RNA metabolic process               |
 |__RNA destabilization____________________________________|
regulation of mRNA catabolic process                       |
 |__regulation of mRNA stability___________________________|
 |__positive regulation of mRNA catabolic process__________|
positive regulation of mRNA metabolic process              |
 |__positive regulation of mRNA catabolic process__________|
                                                           mRNA destabilization  68 rec.
                                                            |__3'-UTR-mediated mRNA destabilization 5 rec.
                                                            |__miRNA-mediated gene silencing by mRNA destabilization 26 rec.
                                                            |__nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 26 rec.
                                                            |__piRNA-mediated gene silencing by mRNA destabilization 12 rec.
                                                            |   |__transposable element silencing by piRNA-mediated mRNA destabilization 8 rec.
                                                            |__polyadenylation-dependent mRNA catabolic process
                                                            |   |__nuclear polyadenylation-dependent mRNA catabolic process
                                                            |__polyuridylation-dependent mRNA catabolic process
                                                            |__siRNA-mediated gene silencing by mRNA destabilization 1 rec.
                                                            |   |__siRNA-mediated long-distance post-transcriptional gene silencing
                                                            |__transposable element silencing by mRNA destabilization 10 rec.
                                                                |__transposable element silencing by piRNA-mediated mRNA destabilization 8 rec.
                                                                |__transposable element silencing by siRNA-mediated mRNA destabilization
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Is a negative regulation of gene expression
regulation of mRNA stability
RNA destabilization
positive regulation of mRNA catabolic process
Part of
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