FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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Term siRNA-mediated post-transcriptional gene silencing ID (Ontology) GO:0140766 (Gene Ontology)
Definition A post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) elicit silencing of specific target genes. siRNAs are 21-23 nucleotide RNA duplexes that are fully complementary to their target mRNA. siRNAs can be exported and act in other cells, including in germline cells. Once incorporated into a RNA-induced silencing complex (RISC), siRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the mRNA or mRNA translational repression. siRNAs are present in lower animals and plants, but not found in mammals; whereas miRNAs are present in all the animals and in plants.[ PubMed:26372022 ]
Also Known As "gene silencing by siRNA" ; "post-transcriptional gene silencing by siRNA" ; "posttranscriptional gene silencing by siRNA" (for all, see Synonyms field below)
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post-transcriptional gene silencing_______
regulatory ncRNA-mediated gene silencing__|
                                          regulatory ncRNA-mediated post-transcriptional gene silencing
                                           |__siRNA-mediated post-transcriptional gene silencing  1 rec.
                                               |__siRNA-mediated gene silencing by inhibition of translation
                                               |__siRNA-mediated gene silencing by mRNA destabilization 1 rec.
                                                   |__siRNA-mediated long-distance post-transcriptional gene silencing
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Is a regulatory ncRNA-mediated post-transcriptional gene silencing
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Synonyms
  • "gene silencing by siRNA" EXACT
    "post-transcriptional gene silencing by siRNA" EXACT
    "posttranscriptional gene silencing by siRNA" EXACT
    "siRNA-mediated gene silencing" BROAD
    "siRNA-mediated PTGS" EXACT
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