FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term piRNA-mediated gene silencing by mRNA destabilization ID (Ontology) GO:0140991 (Gene Ontology)
Definition A cytoplasmic post-transcriptional gene silencing pathway in which piRNAs direct the cleavage of target mRNAs. The target mRNA, often transcribed from a transposable element, is destabilized by the activity of a PIWI class endonuclease within the piRNA-induced silencing complex. This may also be accompanied by mRNA deadenylation and decapping.[ PubMed:29281264 PubMed:33419460 ]
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       8
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 Genes
 piRNA-mediated gene silencing by mRNA destabilization (all annotations which use CV term, excluding "NOT" statements)       8
     involved_in | piRNA-mediated gene silencing by mRNA destabilization       8
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negative regulation of gene expression
 |__mRNA destabilization___________________________________________
post-transcriptional gene silencing                                |
 |__regulatory ncRNA-mediated post-transcriptional gene silencing__|
regulatory ncRNA-mediated gene silencing                           |
 |__regulatory ncRNA-mediated post-transcriptional gene silencing__|
regulation of mRNA stability                                       |
 |__mRNA destabilization___________________________________________|
RNA destabilization                                                |
 |__mRNA destabilization___________________________________________|
positive regulation of mRNA catabolic process                      |
 |__mRNA destabilization___________________________________________|
                                                                   piRNA-mediated gene silencing by mRNA destabilization  12 rec.
                                                                    |__transposable element silencing by piRNA-mediated mRNA destabilization 8 rec.
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Is a regulatory ncRNA-mediated post-transcriptional gene silencing
mRNA destabilization
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