FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term regulatory ncRNA-mediated post-transcriptional gene silencing ID (Ontology) GO:0035194 (Gene Ontology)
Definition A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation.[ PubMed:11201747 PubMed:11713190 PubMed:15020054 PubMed:15066275 PubMed:18771919 PubMed:32885814 PubMed:33184244 ]
Also Known As "ncRNA-mediated post-transcriptional gene silencing" ; "posttranscriptional gene silencing by RNA" ; "RNA-dependent post-transcriptional gene silencing" (for all, see Synonyms field below)
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      25
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 regulatory ncRNA-mediated post-transcriptional gene silencing (all annotations which use CV term, excluding "NOT" statements)       1     25
     involved_in | regulatory ncRNA-mediated post-transcriptional gene silencing       --      25
 NOT | involved_in | regulatory ncRNA-mediated post-transcriptional gene silencing       --       6
Spanning Tree (Parents/Children)
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post-transcriptional regulation of gene expression
 |__post-transcriptional gene silencing_______
negative regulation of gene expression        |
 |__post-transcriptional gene silencing_______|
 |__regulatory ncRNA-mediated gene silencing__|
                                              regulatory ncRNA-mediated post-transcriptional gene silencing  204 rec.
                                               |__lncRNA-mediated post-transcriptional gene silencing 1 rec.
                                               |__miRNA-mediated post-transcriptional gene silencing 167 rec.
                                               |   |__miRNA-mediated gene silencing by inhibition of translation 15 rec.
                                               |   |__miRNA-mediated gene silencing by mRNA destabilization 26 rec.
                                               |__piRNA-mediated gene silencing by mRNA destabilization 12 rec.
                                               |   |__transposable element silencing by piRNA-mediated mRNA destabilization 8 rec.
                                               |__RNAi-mediated antiviral immune response 5 rec.
                                               |   |__RNAi-mediated antiviral immunity against DNA virus
                                               |   |__RNAi-mediated antiviral immunity against RNA virus 2 rec.
                                               |__siRNA-mediated post-transcriptional gene silencing 1 rec.
                                               |   |__siRNA-mediated gene silencing by inhibition of translation
                                               |   |__siRNA-mediated gene silencing by mRNA destabilization(+) 1 rec.
                                               |__sRNA-mediated post-transcriptional gene silencing
                                               |__transitive RNA interference
                                                   |__3' transitive RNA interference
                                                   |__5' transitive RNA interference
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Is a post-transcriptional gene silencing
regulatory ncRNA-mediated gene silencing
Part of
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Synonyms
  • "cosuppression" RELATED
    "ncRNA-mediated post-transcriptional gene silencing" EXACT
    "post-transcriptional gene silencing by RNA" RELATED
    "posttranscriptional gene silencing by RNA" EXACT
    "PTGS" BROAD
    "quelling" RELATED
    "RNA interference" BROAD
    "RNA-dependent post-transcriptional gene silencing" EXACT
    "RNA-mediated post-transcriptional gene silencing" EXACT
    "RNA-mediated posttranscriptional gene silencing" EXACT
    "RNAi" BROAD
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-426496 "Post-transcriptional silencing by small RNAs"
Wikipedia:RNA_interference