FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term regulation of mRNA stability ID (Ontology) GO:0043488 (Gene Ontology)
Definition Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       5
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 Genes
 regulation of mRNA stability (all annotations which use CV term, excluding "NOT" statements)       5
     involved_in | regulation of mRNA stability       5
Spanning Tree (Parents/Children)
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regulation of catabolic process
 |__regulation of RNA stability_____________________
 |__regulation of mRNA catabolic process____________|
regulation of gene expression                       |
 |__regulation of mRNA catabolic process____________|
post-transcriptional regulation of gene expression  |
 |__regulation of RNA stability_____________________|
regulation of RNA metabolic process                 |
 |__regulation of RNA stability_____________________|
regulation of biological quality                    |
 |__regulation of RNA stability_____________________|
regulation of mRNA metabolic process                |
 |__regulation of mRNA catabolic process____________|
                                                    regulation of mRNA stability  84 rec.
                                                     |__mRNA destabilization 68 rec.
                                                     |   |__3'-UTR-mediated mRNA destabilization 5 rec.
                                                     |   |__miRNA-mediated gene silencing by mRNA destabilization 26 rec.
                                                     |   |__nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 26 rec.
                                                     |   |__piRNA-mediated gene silencing by mRNA destabilization(+) 12 rec.
                                                     |   |__polyadenylation-dependent mRNA catabolic process(+)
                                                     |   |__polyuridylation-dependent mRNA catabolic process
                                                     |   |__siRNA-mediated gene silencing by mRNA destabilization(+) 1 rec.
                                                     |   |__transposable element silencing by mRNA destabilization(+) 10 rec.
                                                     |__mRNA stabilization 9 rec.
                                                     |   |__3'-UTR-mediated mRNA stabilization 3 rec.
                                                     |   |__CRD-mediated mRNA stabilization 2 rec.
                                                     |__regulation of 3'-UTR-mediated mRNA stabilization 1 rec.
                                                     |   |__negative regulation of 3'-UTR-mediated mRNA stabilization
                                                     |   |__positive regulation of 3'-UTR-mediated mRNA stabilization 1 rec.
                                                     |__regulation of mitochondrial mRNA stability 4 rec.
                                                     |__regulation of mRNA stability involved in cellular response to UV
                                                     |__regulation of mRNA stability involved in response to stress
                                                     |   |__regulation of mRNA stability involved in response to oxidative stress
                                                     |__regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2 rec.
                                                         |__negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(+)
                                                         |__positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2 rec.
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Is a regulation of RNA stability
regulation of mRNA catabolic process
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Reactome:R-HSA-428359 "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"
Reactome:R-HSA-450531 "Regulation of mRNA stability by proteins that bind AU-rich elements"