FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Aberration: Dmel\Dp(2;2)RanGAPSd
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General Information
Symbol
Dp(2;2)RanGAPSd
Species
D. melanogaster
Name
FlyBase ID
FBab0038630
Feature type
intrachromosomal_duplication
Also Known As
Sd
Computed Breakpoints include
Features within 37E1--37E1
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
natural population
(Powers and Ganetzky, 1991)
Class of aberration (relative to wild type)
intrachromosomal_duplication
(FlyBase, 2007)
Class of aberration (relative to progenitor)
tandem_duplication
(Merrill et al., 1999)
Breakpoints

[];[]

(Merrill et al., 1999)
Causes alleles
RanGAPSd
(Gell and Reenan, 2013, Merrill et al., 1999, Powers and Ganetzky, 1991)
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments

Tandem duplication replacing the wild type 6.5kb EcoRI fragment with an 11.5kb EcoRI fragment. The duplication results in two copies of the RanGAP gene (and the Hs2st gene nested within it) being present in Dp(2;2)RanGAPSd. The organisation of the RanGAP and Hs2st genes in the proximal half of the duplication is essentially the same as in RanGAP[+]. The Hs2st gene in the distal half of the duplication encodes a wild-type protein. The remaining distal transcript encodes a mutant version of RanGAP, whose C-terminal portion differs from wild type beginning at the duplication junction. This results in a truncated RanGAP protein that lacks the C-terminal 234 amino acids.

(Merrill et al., 1999)

A 5kb tandem duplication is uniquely associated with all RanGapSD chromosomes.

(Powers and Ganetzky, 1991)
Comments on Cytology
Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Hs2st
(Merrill et al., 1999)
Partially duplicated
RanGAP
(Merrill et al., 1999)
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
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    Phenotypic Data
    In combination with other aberrations
    NOT in combination with other aberrations
    Stocks (7)
    Notes on Origin
    Discoverer
     

    Analysis of different SD chromosomes containing the Dp(2;2)RanGapSD duplication suggests that the duplication arose only once; all SD chromosomes (9 independently isolated chromosomes have been tested) have the same constellation of polymorphic restriction sites in a 50kb region that extends 20kb distal and 28kb proximal to the duplication, and have one of two conserved haplotypes in the region that is 28-43kb proximal to the duplication. Two different SD chromosomes, SD-Roma and SD-VO17, both lack the pericentric and/or 2R inversions that are typically associated with SD chromosomes and were isolated from Mediterranean populations. If the duplication arose only once, it may have originated in the Mediterranean region on a chromosome that was free of inversions. The specific inversions associated with the different SD chromosomes would then have arisen subsequently after the geographic spread of these chromosomes.

    (Powers and Ganetzky, 1991)
    Balancer / Genotype Variants of the Aberration
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (5)
    Reported As
    Symbol Synonym
    Dp(2;2)RanGAPSD
    Dp(2;2)RanGAPSd
    Dp(2;2)RanGapSD
    SD
    (Johansen, 1996, Haig and Bergstrom, 1995)
    Sd
    (Powers and Ganetzky, 1991)
    Name Synonyms
    Secondary FlyBase IDs
      References (34)