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General Information
Symbol
Dmel\ovoD3
Species
D. melanogaster
Name
FlyBase ID
FBal0013377
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

A5064717T

Reported nucleotide change:

A1336T

Amino acid change:

K226M | ovo-PB; K97M | ovo-PC; K226M | ovo-PE

Reported amino acid change:

K97M

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Mutation creates a new in-frame AUG codon in the open reading frame in exon 2.

Nucleotide substitution: A1336T.

Amino acid replacement: K97M.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ovoD3/+ females carrying ovoD1r+ produce embryos, but they die before hatching with gross and variable defects in cuticle differentiation including holes, especially anteriorly, segment deletions and fusions, failed head involution and deletions of anterior elements of the mouthparts.

Females carrying ovoD3 in an ovo-/+ background show dominant female sterility. The eggs produced by these females are flaccid and have chorion defects such as fused dorsal appendages.

The dominant ovoD3 phenotype is significantly enhanced by one copy of Df(2R)vg135, Df(2R)stil-A or Df(2R)stil-B.

In heterozygous females oogenesis is arrested.

Affect is weaker than for ovoD2. ovoD3/+ females produce many eggs that look almost normal except for the permeability of the membrane and frequent fusion of their dorsal appendages.

Oogenesis is nearly normal in heterozygous females.

Permeable eggs.

Heterozygous females develop normally and can lay eggs although they are flaccid and degenerate.

Ovaries usually contain many late stage eggs. Fertility is restored by the presence of two copies of ovo+.

Most of the egg chambers of heterozygous females develop into eggs that are laid (more than 30% of the wild-type number of eggs are laid per day). The eggs are usually permeable to neutral red and have fused dorsal appendages. The soma is wild-type. Transheterozygotes with either ovoM1, ovoM2 or ovoD1rv20 have germ cells resembling early spermatocytes.

Mutant gene activity works in opposition to wild type activity. Viable. Male germ line is fertile, female germ line has permeable eggs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

This maternal effect lethality can be rescued by ovoΔa2, ovoamk or ovoΔap.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

The dominant ovoD3 mutation has been reverted to a recessive loss of function mutation by insertion of a copia element.

Partially suppresses the female-specific gonadal dysgenesis caused by hybrid dysgenesis at 27.5oC.

Shows a dominant interaction with otu alleles: more extreme mutant phenotype as assayed by reduction in number of egg chambers at stage 10 or further developed.

Parental strain: fs(1)N.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (19)