FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Tlr6
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General Information
Symbol
Dmel\Tlr6
Species
D. melanogaster
Name
FlyBase ID
FBal0016841
Feature type
allele
Associated gene
Dmel\Tl
Associated Insertion(s)
Carried in Construct
Also Known As
TlrB1
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Schneider et al., 1991)
Mutagen
ethyl methanesulfonate
(Lindsley and Zimm, 1992)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C3251T. Amino acid replacement: H893Y. This mutation is in the cytoplasmic domain of the protein.

(Schneider et al., 1991)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:26,840,530..26,840,530 [+]
Nucleotide change:

C26840530T

Reported nucleotide change:

C3251T

Amino acid change:

H893Y | Tl-PB; H893Y | Tl-PC; H893Y | Tl-PD

Reported amino acid change:

H893Y

Comment:

This mutation is in the cytoplasmic domain of the protein.

(Schneider et al., 1991)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Recessive.

      (Lindsley and Zimm, 1992)

      Embryos from homozygous females are weakly dorsalised.

      (Schneider et al., 1991)

      Moderate dorsalization of embryo.

      (Gerttula et al., 1988)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Completely penetrant phenotype.

      (Gerttula et al., 1988)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Tlr6
      TlrB1
      (Yagi and Hayashi, 1997, Lindsley and Zimm, 1992, Schneider et al., 1991, Gerttula et al., 1988)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)