FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mlenap-ts3
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General Information
Symbol
Dmel\mlenap-ts3
Species
D. melanogaster
Name
FlyBase ID
FBal0023800
Feature type
allele
Associated gene
Dmel\mle
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

heat sensitive gain of function allele

Mutagen
Nature of the Allele
Allele class

heat sensitive gain of function allele

(Kernan et al., 1991)
Mutagen
ethyl methanesulfonate
gamma ray
(Kernan et al., 1991)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C1664G. Amino acid replacement: T415S. Also carries a net insertion of 6bp (replacement of 1bp with a 7bp insert) within an intron (this change is not responsible for the mutant phenotype).

(Kernan et al., 1991)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      male viable when homozygous

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Mutant phenotype can be rescued by P element mediated transformation of a wild type mle gene copy.

      (Kernan et al., 1991)

      fails to complement mlenap-ts1 paralysis

      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      mlenap-ts3
      nap1-1
      napts3
      (Kernan et al., 1991)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0032156
      References (3)