FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Gβ76C1
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General Information
Symbol
Dmel\Gβ76C1
Species
D. melanogaster
Name
FlyBase ID
FBal0033682
Feature type
allele
Associated gene
Dmel\Gβ76C
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Elia et al., 2005)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: C293Y.

    (Dolph et al., 1994)

    Single amino acid change.

    (Yarfitz et al., 1994)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3L:19,689,302..19,689,302 [+]
    Nucleotide change:

    G19689302A

    Amino acid change:

    C293Y | Gbeta76C-PA

    Reported amino acid change:

    C293Y

    Comment:

    Site of nucleic acid difference in mutant inferred by FlyBase based on reported amino acid change.

    (Dolph et al., 1994)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutant flies show normal responses to CO[[2]].

        (Yao and Carlson, 2010)

        Gβ76C1 mutants show a 2-log reduction in sensitivity to light, along with a modified waveform of the light-induced current. Heterozygous Gβ76C1/+ mutants show only a minor reduction in sensitivity to light.

        Whole cell patch-clamp recording of dark-adapted Gβ76C1 mutant photoreceptor cells shows spontaneous, unitary, inward currents that are similar in shape to the single photon responses known as quantum bumps. Homozygous and heterozygous Gβ76C1 mutants exhibit an increase in bump frequency compared to wild-type. The high rate of spontaneous bumps is not affected by reduced levels of rhodopsin.

        (Elia et al., 2005)

        The amplitude of light induced quantum bumps in the photoreceptors of Gβ76C1 mutants is reduced compared to wild-type (when ATP is present in the intracellular solution during recordings).

        (Hardie et al., 2002)

        Blue light stimulation of phospholipase C is deficient in Gβ76C1 flies. Gβ76C+tDa restores the blue light stimulation of phospholipase C in Gβ76C1 flies to 73% of control levels.

        (Running Deer et al., 1995)

        Whole cell patch clamp recordings demonstrate photoreceptors have a dramatic loss of light sensitivity.

        (Dolph et al., 1994)

        Mutation does not cause retinal degradation, photoreceptors exhibit normal morphology. Light-dependent 35S-labelled guanosine 5'-3-0-(thio)triphosphate (35S GTPγS) binding is severely reduced. Expression of P{Gβe+} can rescue the binding defect.

        (Yarfitz et al., 1994)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        Gβ76C1 has abnormal neurophysiology phenotype, suppressible by Gαq1

        (Elia et al., 2005)
        Suppressor of
        Statement
        Reference

        Gβ76C1 is a suppressor of abnormal neurophysiology phenotype of Gαq1

        (Elia et al., 2005)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Gβ76C1/+ ; Gα49B1/+ double mutants exhibit almost normal sensitivity to light and no spontaneous activity in the dark.

        (Elia et al., 2005)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Gβ76C1 is rescued by Gβ76C+tDa

        (Dolph et al., 1994)
        Partially rescued by

        Gβ76C1 is partially rescued by Gβ76C+tDa

        (Running Deer et al., 1995)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (2)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Reduction in levels of Gβ76C protein.

        (Dolph et al., 1994)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        Gβe1
        (Kosloff et al., 2003)
        Gβ76C1
        (Yao and Carlson, 2010)
        Gβe1
        (Elia et al., 2005)
        Gβe1
        (Hardie et al., 2002)
        Name Synonyms
        Secondary FlyBase IDs
          References (7)