FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RafSu3
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General Information
Symbol
Dmel\RafSu3
Species
D. melanogaster
Name
FlyBase ID
FBal0039754
Feature type
allele
Associated gene
Dmel\Raf
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lu et al., 1994)
Progenitor genotype
Cytology
Description

Amino acid replacement: F290I. Mutation in the CR1 domain.

(Lu et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:2,341,753..2,341,753 [+]
Nucleotide change:

T2341753A

Amino acid change:

F247I | Raf-PA; F247I | Raf-PE

Reported amino acid change:

F290I

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Lu et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes are viable and morphologically normal. Embryos derived from phlSu3, Ras85DΔC40B double mutant germ cells die during embryogenesis with cuticles indistinguishable from those of Ras85DΔC40B mutants. Animals doubly mutant for phlSu3 and torrv66 are completely non-viable and resemble torrv66 mutants.

      (Li et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially complements

      Raf1

      (Lu et al., 1994)
      Comments

      phl1 homozygous lethality and hemizygous male eye defect can be partially rescued by one copy of phlSu3. phl1/phl7 heterozygotes can be completely rescued by one copy of phlSu3.

      (Lu et al., 1994)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Relative suppressor ability: phlSu3 > phlSu8 > phlSu5 > phlSu2.

      (Lu et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      DrafR217L,F290I
      (Li et al., 1998)
      RafSu3
      Su(D-raf)3
      (Lu et al., 1994)
      Su(DrafC110)3
      (Li et al., 1998)
      phlSu3
      Name Synonyms
      Secondary FlyBase IDs
        References (2)