FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\enαTub84B.PZ
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General Information
Symbol
Dmel\enαTub84B.PZ
Species
D. melanogaster
Name
α-Tubulin at 84B promoter construct of Zecca
FlyBase ID
FBal0045589
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Carried in construct
Cytology
Description

FRT cassette has been excised, juxtaposing αTub84B promoter with en coding sequences.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Clones in the wing disc expressing enαTub84B.PZ and of posterior origin are strictly confined to the posterior territory. 8 out of 16 clones expressing enαTub84B.PZ and of anterior origin occupy positions normally taken only by posterior cells.

Clones expressing enαTub84B.PZ that span a small area in the male external genitalia cause duplications of bristles. A large number of this type of clone are seen on the lateral lobe and claspers. Clones spanning a larger area in the male external genitalia result in pattern reorganisation of the neighbouring areas in a mirror image symmetry. The penis apparatus also shows duplications of various parts including the hypandrium, hypandrial bristles and apodeme. In females, clones produce mirror image duplication of thorn bristles and of the long bristles in the opposite direction in the vaginal plates. In some cases the thorn bristles are absent. The cells expressing enαTub84B.PZ contribute to only a small portion of the altered pattern.

Expression of enαTub84B.PZ in the anterior compartment of the haltere causes its transformation to wing.

Clones expressing enαTub84B.PZ in the posterior tergite are transformed into posterior hairy zone (PHZ), whereas more anterior clones contain both PHZ and intersegmental membrane (ISM). Ectopic ISM is always induced anteriorly to ectopic PHZ, and is never induced posterior to the second row of microchaetae. Larger clones cause wild-type cells at the posterior of the clone to produce posterior tergite structures. Clones in the anterior tergite produce PHZ with reversed trichome orientation, while clones in the posterior tergite produce PHZ with normal polarity.

Wing clones in the posterior compartment develop normally. Wing clones in the anterior compartment fall into two types: neutral and reorganizing. Neutral clones are morphologically normal and small or close to the compartment boundary. Reorganizing clones are found in the anterior and are larger than neutral clones in corresponding positions. Where reorganizing clones contribute to dorsal and ventral surfaces they cause a symmetric reorganization of pattern. Where reorganizing clones are restricted to dorsal or ventral surfaces do not alter the size/shape of the wing, but alter the behavior of surrounding anterior cells on the same surface e.g. to cause circular veins. Response of cells to the clone depends on the distance from the clone. Altered wing pattern is similar to that seen for hhαTub84B.PB though cells in enαTub84B.PZ clones behave like posterior cells rather than anterior cells as in hhαTub84B.PB clones. Clones spanning the normal position of the copmpartment boundary sometimes fail to form part or all of the longitudinal vein 4.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Exists in clones, not reported as being germ-line transmitted.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
enαTub84B.PZ
Name Synonyms
α-Tubulin at 84B promoter construct of Zecca
Secondary FlyBase IDs
    References (7)