FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Acp26Aa1
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General Information
Symbol
Dmel\Acp26Aa1
Species
D. melanogaster
Name
line 1
FlyBase ID
FBal0047984
Feature type
allele
Associated gene
Dmel\Acp26Aa
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Herndon and Wolfner, 1995)
Mutagen
ethyl methanesulfonate
(Herndon and Wolfner, 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: K43term.

(Herndon and Wolfner, 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:5,893,689..5,893,689 [-]
Nucleotide change:

A5893689T

Amino acid change:

K43term | Acp26Aa-PA

(Herndon and Wolfner, 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The early egg production of wild-type females housed with Acp26Aa1/Df(2L)PM101 males is significantly lower than that of wild-type females housed with Acp26Aa2/Df(2L)PM101 males. The lifetime egg production of wild-type females mated with Acp26Aa1/Df(2L)PM101 males is not significantly different than that of wild-type females mated with Acp26Aa2/Df(2L)PM101 males. The early (days 3 and 6) eggs laid by wild-type females mated with Acp26Aa2/Df(2L)PM101 males are significantly less fertile than those laid by wild-type females mated with Acp26Aa1/Df(2L)PM101 males. The survival of wild-type females mated with Acp26Aa1/Df(2L)PM101 males is not significantly different from the survival of wild-type females mated with Acp26Aa2/Df(2L)PM101 males.

      (Chapman et al., 2001)

      The number of eggs passing through the genital tracts of females mated to Acp26Aa1 males is less than half the number seen in controls, suggesting a low ovulation rate. Egg deposition is initiated at the same time as controls. The mates of Acp26Aa1 males are specifically defective in the stimulated release of oocytes by their ovaries. The effect is most pronounced on numbers of eggs found in the lateral oviducts and this effect was seen very soon post mating. No accumulation of undeposited eggs is seen.

      (Heifetz et al., 2000)

      Male flies are viable and morphologically normal externally and internally, expression of other male product genes is normal. Lack of Acp26Aa in males causes a small but statistically significant decrease in egg laying by their mates but only for 1 day after mating. Fertility, receptivity and sperm competition in mated females is not affected by lack of Acp26Aa.

      (Herndon and Wolfner, 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Acp26Aa1
      (Rubinstein and Wolfner, 2013, McGraw et al., 2008)
      Name Synonyms
      line 1
      (Herndon and Wolfner, 1995)
      Secondary FlyBase IDs
        References (6)