FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cnnB4
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General Information
Symbol
Dmel\cnnB4
Species
D. melanogaster
Name
FlyBase ID
FBal0100378
Feature type
allele
Associated gene
Dmel\cnn
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Kao and Megraw, 2009)
Mutagen
ethyl methanesulfonate
(Vaizel-Ohayon and Schejter, 1999)
Progenitor genotype
Cytology
Description

Amino acid replacement: R1141H. Nucleotide substitution: CGC codon is replaced by a CAC codon. Missense mutation within the extreme carboxy terminal portion of the coding sequence.

(Vaizel-Ohayon and Schejter, 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:13,440,097..13,440,097 [-]
Nucleotide change:

G13440097A

Reported nucleotide change:

G?A

Amino acid change:

R1141H | cnn-PA; R1113H | cnn-PB; R1083H | cnn-PD; R1123H | cnn-PE; R1313H | cnn-PJ; R1371H | cnn-PL; R1113H | cnn-PM; R1113H | cnn-PN

Reported amino acid change:

R1141H

(Vaizel-Ohayon and Schejter, 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cnnB4 embryos exhibit a 'linked spindles' phenotype and cleavage furrow assembly is severely deficient, though centrosomes are partially competent to organize actin into cleavage furrows. In contrast, cnnB4 centrosomes are very proficient microtubule organizing centers, producing astral microtubules similar to wild type.

      (Kao and Megraw, 2009)

      Embryos from cnnHK21 mothers show an disrupted cortical microfilament organisation during syncitial development.

      (Vaizel-Ohayon and Schejter, 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      cnnB4
      (Ryder et al., 2020, Lerit et al., 2015, Kao and Megraw, 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)