FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tutl2
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General Information
Symbol
Dmel\tutl2
Species
D. melanogaster
Name
FlyBase ID
FBal0122878
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Cytology
Description

Imprecise excision of the P{lacW} element resulting in deletion of tutl sequences.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

General morphology of the mutant larvae and adults is normal. Most homozygotes are able to survive to adulthood if competition with heterozygous siblings is eliminated. However, competition from heterozygous siblings results in the death of homozygous animals (85-100% lethality) before adulthood. Homozygous larvae have a severely compromised ability to roll over from an inverted position; the time required to right themselves is significantly longer than control larvae. Homozygous adults cannot fly, although they walk normally and energetically on a level surface. The jump response is intact and robust, but attempts at flight result in the flies flipping themselves onto their backs, where continued efforts to fly are shown by the adults flapping their wings at high speeds (this only results in the flies spinning frantically in circles). Adults that become inverted are rarely able to right themselves, despite what appears to be an intense effort to roll over. Only 12-36% of adults are able to roll over after 60 seconds, in contrast to wild-type which roll over immediately, almost always in less than one second. No alterations in brain morphology (including the superior lateral protocerebrum and regions associated with the mushroom bodies) are seen in mutant adults.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)