FlyBase Allele Report: Dmel\TfAP-2[stummelbein]

General Information

Symbol

Dmel\TfAP-2^stummelbein

Species

D. melanogaster

Name

stummelbein

FlyBase ID

FBal0123324

Feature type

allele

Associated gene

Dmel\TfAP-2

Associated Insertion(s)

P{Mcp-w#14}TfAP-2^stummelbein

Carried in Construct

Also Known As

w#14.29

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Kerber et al., 2001)

Mutagen

P-element activity

(Kerber et al., 2001)

Progenitor genotype

Associated Insertion(s)

P{Mcp-w#14}TfAP-2^stummelbein

Cytology

Description

P{Mcp-w#14} insertion is located 87bp upstream of the first exon of the less extensive of the two splice variants of the AP-2 transcription unit, and thus is within the first intron of the more extensive of the two splice variants of the AP-2 transcription unit.

(Kerber et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:21,608,036..21,608,036 [+]

(Kerber et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Kerber et al., 2001)

viable (with Df(3L)croc-2)

(Kerber et al., 2001)

viable (with TfAP-2²)

(Kerber et al., 2001)

viable (with TfAP-2¹⁵)

(Kerber et al., 2001)

visible

(Kerber et al., 2001)

visible (with Df(3L)croc-2)

(Kerber et al., 2001)

visible (with TfAP-2²)

(Kerber et al., 2001)

visible (with TfAP-2¹⁵)

(Kerber et al., 2001)

Phenotype Manifest In

leg

(Kerber et al., 2001)

leg (with Df(3L)croc-2)

(Kerber et al., 2001)

leg (with TfAP-2²)

(Kerber et al., 2001)

leg (with TfAP-2¹⁵)

(Kerber et al., 2001)

leg joint

(Kerber et al., 2001)

leg joint (with Df(3L)croc-2)

(Kerber et al., 2001)

leg joint (with TfAP-2²)

(Kerber et al., 2001)

leg joint (with TfAP-2¹⁵)

(Kerber et al., 2001)

Detailed Description

Statement

Reference

Homozygotes are viable but have short legs. The joints of the legs are missing. The sex combs and transverse rows are correctly positioned. The first leg is most strongly affected. The second and third legs are slightly longer but also fail to form joints.

(Kerber et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

TfAP-2¹⁵

(Kerber et al., 2001)

TfAP-2²

(Kerber et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Etymology: 'stummelbein' is German for 'short leg'. Reversion analysis indicates that the P{Mcp-w#14} insertion is the cause of the mutant phenotype.

(Kerber et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

AP-2^stummelbein

TfAP-2^stummelbein

dAP-2^stummelbein

(Kerber et al., 2001)

Name Synonyms

stummelbein

(Kerber et al., 2001)

Secondary FlyBase IDs

References (1)

Report Sections

Open Close