FlyBase Allele Report: Dmel\osk[norka]

General Information

Symbol

Dmel\osk^norka

Species

D. melanogaster

Name

FlyBase ID

FBal0146965

Feature type

allele

Associated gene

Dmel\osk

Associated Insertion(s)

P{GAL4}osk^norka

Carried in Construct

Also Known As

norka, D0067

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Dubnau et al., 2003)

Progenitor genotype

Associated Insertion(s)

P{GAL4}osk^norka

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GAL4}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning

(Dubnau et al., 2003)

abnormal learning | recessive

(van Swinderen et al., 2009)

abnormal memory

(Dubnau et al., 2003, Dubnau et al., 2003)

abnormal neurophysiology | recessive

(van Swinderen et al., 2009)

abnormal visual behavior | recessive

(van Swinderen et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

osk^norka mutants show significantly greater optomotor responsiveness than wild type flies in an optomotor maze paradigm. In contrast to wild type flies, optomotor responses in osk^norka mutants are not significantly affected when a distraction is present. osk^norka optomotor performance is not significantly increased following repeated exposure to the maze.

Unlike wild type flies, osk^norka flies fail to learn to avoid visuals associated with shaking.

osk^norka flies have attenuated baseline brain responses when exposed to visual objects alone, compared to wild type flies. Mutant flies also exhibit an aberrant response to novel objects.

(van Swinderen et al., 2009)

Homozygous osk^norka mutant flies do not show any change in sensitivity to ethanol vapor compared to controls.

(Berger et al., 2008)

In memory tests, mutants perform at 87% of wild-type after a single training session, at 8% after spaced training.

(Dubnau et al., 2003)

Homozygotes exhibit severe defects in one-day memory after spaced training.

(Dubnau et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Etymology: Given the name "norka", after one of Pavlov's dogs.

(Dubnau et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

D0067

(van Swinderen et al., 2009, Berger et al., 2008, Dubnau et al., 2003)

norka

(Berger et al., 2008, Dubnau et al., 2003)

osk^norka

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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