FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\WRNexoe04496
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General Information
Symbol
Dmel\WRNexoe04496
Species
D. melanogaster
Name
FlyBase ID
FBal0161005
Feature type
allele
Associated gene
Dmel\WRNexo
Associated Insertion(s)
PBac{RB}WRNexoe04496
Carried in Construct
Also Known As
CG7670e04496
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Boubriak et al., 2009)
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{RB}WRNexoe04496
Cytology
Description

Insertion in the 5' UTR.

(Saunders et al., 2008)
Allele components
Component
Use(s)
Inserted element
PBac{RB}
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Werner syndrome
      CEA
      (Saunders et al., 2008)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mitotic recombination rates are approximately doubled in WRNexoe04496/Df(3R)Exel6178 flies, compared to WRNexoe04496/WRNexoe04496; rates of recombination in WRNexoe04496/WRNexoD229V are much lower (though still higher than WRNexoe04496/+).

      (Boubriak et al., 2009)

      Homozygotes have no gross morphological abnormality.

      Eggs derived from homozygous females do not hatch.

      Homozygous larvae are very sensitive to camptothecin (CPT) compared to controls. Surviving adults have roughened eyes and many die as pharate adults.

      Clones are recovered in the wing at a very high frequency in homozygous flies compared to control heterozygotes. In addition, some clones in the homozygous wing blades are very large, while the rate clones seen in heterozygous flies are all single cells. The majority of the clones recovered in the homozygous flies appear to be the result of mitotic DNA recombination events.

      (Saunders et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG7670e04496
      (Boubriak et al., 2009, Saunders et al., 2008)
      WRNexoe04496
      Name Synonyms
      Secondary FlyBase IDs
        References (4)