FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\gwl180
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General Information
Symbol
Dmel\gwl180
Species
D. melanogaster
Name
FlyBase ID
FBal0190967
Feature type
allele
Associated gene
Dmel\gwl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: G69E.

    (Yu et al., 2004)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:18,747,292..18,747,292 [+]
    Nucleotide change:

    G18747292A

    Amino acid change:

    G69E | gwl-PA; G69E | gwl-PB

    Reported amino acid change:

    G69E

    Comment:

    Site of nucleic acid difference inferred by FlyBase based on reported amino acid change.

    (Yu et al., 2004)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygotes die as first or second instar larvae.

        gwl716/gwl180 larval brains are normal in size. The mitotic index of mutant larval neuroblasts is increased compared to wild type. The proportion of cells in early mitotic stages (prophase and prometaphase) is increased and the proportion of cells in late mitotic stages (metaphase, anaphase and telophase) is decreased in the mutant cells compared to wild type.

        Some adult gwl716/gwl180 escapers are seen. These eclose several days late and have rough eyes and wing defects. The females are sterile and do not lay eggs. The males are sterile.

        gwlSr18/gwl180 oocytes fail to maintain metaphase I.

        (Kim et al., 2012)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        gwl180/gwlSr18 has abnormal meiotic cell cycle | oogenesis phenotype, suppressible | partially by tws[+]/twsj11C8

        (Kim et al., 2012)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        twsj11C8/+ suppresses many of the gwl716/gwl180 mutant phenotypes, with adults eclosing at the normal time with normal wing and eye morphologies. Males are fertile, but females lay eggs that do not develop. The mitotic index of mutant larval neuroblasts is near normal.

        twsj11C8/+ significantly rescues the meiotic maturation defect of gwlSr18/gwl180 oocytes.

        (Kim et al., 2012)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        gwl180
        (Kim et al., 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)