FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dscam1ΔR265
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General Information
Symbol
Dmel\Dscam1ΔR265
Species
D. melanogaster
Name
FlyBase ID
FBal0193893
Feature type
allele
Associated gene
Dmel\Dscam1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Chen et al., 2006)
Progenitor genotype
P{PZ}Dscam105518
(Chen et al., 2006)
Cytology
Description

Imprecise excision of the P{PZ} element, resulting in deletion of the Dscam gene from position 15,522 (the intronic region of exon 4.1) to position 17,453 (20bp into the 5' intronic region of exon 4.7). Nucleotide positions correspond to sequence accession AF260530.1.

(Chen et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      posterior scutellar bristle & mechanosensory neuron

      (Chen et al., 2006)

      posterior scutellar bristle & mechanosensory neuron (with Dscam121)

      (Chen et al., 2006)

      posterior scutellar bristle & mechanosensory neuron (with Dscam1ΔR272)

      (Chen et al., 2006)
      Detailed Description
      Statement
      Reference

      95% of DscamΔR265 flies exhibit defects in axonal branching posterior Scutellar (pSc) neurons. These include the following phenotypes that are never observed in wild-type animals (accompanied by the percentage of neurons affected): formation of ectopic branches (13.8%), formation of an ectopic branch that crosses the midline (6.2%) and contralateral branch extension (6.3%). These neurons also show deviations that are only rarely seen in wild-type flies (the wild-type vs the mutant penetrance is shown in brackets): formation of an ectopic mesothoracic branch (16 vs 70%), inverted branch order (3.3 vs 12.7%), and an incomplete midline-crossing branch (6.6 vs 12.7%). DscamΔR265/+ flies show these phenotypes but at a much lower penetrance than homozygotes. Likewise, the penetrance of axonal phenotypes is lower in DscamΔR265/DscamΔR272 transheterozygotes than in either homozygote. In contrast, DscamΔR265/Dscam21 flies show an enhancement in the number of ectopic axonal branches produced compared to DscamΔR265 homozygotes.

      (Chen et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Analysis of the exon 4 sequences confirms the absence of alternative exons 4.2 to 4.6 in transcripts from DscamΔR265 alleles and shows a compensatory upregulation of the remaining alternative exon 4 sequences.

      (Chen et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Dscam1ΔR265
      DscamΔR265
      (Chen et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)