FlyBase Allele Report: Dmel\gfzf[Su(Kpn)1]

General Information

Symbol

Dmel\gfzf^Su(Kpn)1

Species

D. melanogaster

Name

FlyBase ID

FBal0212661

Feature type

allele

Associated gene

Dmel\gfzf

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Provost et al., 2006)

Mutagen

ethyl methanesulfonate

(Provost et al., 2006)

Progenitor genotype

Cytology

Description

Amino acid replacement: R169C.

(Provost et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:7,149,593..7,149,593 [-]

Nucleotide change:

C7149593T

Amino acid change:

R169C | gfzf-PB; R169C | gfzf-PE

Reported amino acid change:

R169C

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Provost et al., 2006)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Provost et al., 2006)

lethal (with Df(3R)Antp7)

(Provost et al., 2006)

lethal (with Df(3R)Antp17)

(Provost et al., 2006)

lethal (with Df(3R)dsx2M)

(Provost et al., 2006)

lethal (with gfzf^AP434)

(Provost et al., 2006)

lethal (with gfzf^BU640)

(Provost et al., 2006)

lethal (with gfzf^BW914)

(Provost et al., 2006)

lethal (with gfzf^BX123)

(Provost et al., 2006)

lethal (with gfzf^CK438)

(Provost et al., 2006)

lethal (with gfzf^CX322)

(Provost et al., 2006)

lethal (with gfzf^CZ811)

(Provost et al., 2006)

lethal (with gfzf^Su(Kpn)2)

(Provost et al., 2006)

lethal (with gfzf^Su(Kpn)3)

(Provost et al., 2006)

viable (with gfzf^AB621)

(Provost et al., 2006)

viable (with gfzf^AB924)

(Provost et al., 2006)

viable (with gfzf^CL1027)

(Provost et al., 2006)

viable (with gfzf^CU338)

(Provost et al., 2006)

viable (with gfzf^DC727)

(Provost et al., 2006)

viable (with gfzf^DC806)

(Provost et al., 2006)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous gfzf^Su(Kpn)1, or trans-heterozygous gfzf^Su(Kpn)1/gfzf^Su(Kpn)2, mutants are lethal at the embyro/first larval instar interphase. They also exhibit an autonomous small imaginal disc phenotype.

(Provost et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

gfzf^Su(Kpn)1 is unable to suppress the lethal interaction between pn^18a and endogenous awd^K.

When females that are homozygous for pn^18a and heterozygous for gfzf^Su(Kpn)1 are crossed with males homozygous for awd^K, no males that are hemizygous for pn^18a, heterozygous for gfzf^Su(Kpn)1, and heterozygous for awd^K are recovered. In contrast, hundreds of female progeny that are heterozygous for pn^18a, heterozygous for gfzf^Su(Kpn)1, and heterozygous for awd^K are recovered.

gfzf^Su(Kpn)1 can suppress the lethal interaction between pn^18a and transgenic awd^Kpn.cPa.

When females that are homozygous for pn^18a and heterozygous for gfzf^Su(Kpn)1 are crossed with males homozygous for the transgenic awd^Kpn.cPa, hundreds of both female and male progeny that are hetero/hemi-zygous for pn^18a, and heterozygous for gfzf^Su(Kpn)1, and heterozygous for awd^Kpn.cPa are recovered. The ratio of males to females is 0.65, indicating suppression of the awd^Kpn.cPa 'Killer of prune' phenotype.

(Provost et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Based on the extent of suppression of pn^18a-awd^Kpn.cPa lethality, the following gfzf alleles can be ranked from the strongest to the weakest as follows: gfzf^Su(Kpn)2 > gfzf^BU640 > gfzf^DC727 > gfzf^AP320 > gfzf^CK438 > gfzf^CZ811 > gfzf^Su(Kpn)1 > gfzf^AP434 > gfzf^CX322 > gfzf^BX123 > gfzf^BW914 = gfzf^AB621 > gfzf^Su(Kpn)3 > gfzf^BS304 > gfzf^CU338 > gfzf^DC806 = gfzf^CL1027 > gfzf^AV739 > gfzf^AB924.

(Provost et al., 2006)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Su(Kpn)¹

(Provost et al., 2006)

gfzf^Su(Kpn)1

Name Synonyms

Suppressor of Killer of prune

(Provost et al., 2006)

Secondary FlyBase IDs

References (1)

Report Sections

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