FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Msh668
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General Information
Symbol
Dmel\Msh668
Species
D. melanogaster
Name
FlyBase ID
FBal0212801
Feature type
allele
Associated gene
Dmel\Msh6
Associated Insertion(s)
P{5'EPgy2}Msh668
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Sekelsky, 2008.1.22, Radford et al., 2007)
Progenitor genotype
P{EPgy2}Msh6EY07308
(Sekelsky, 2008.1.22)
Associated Insertion(s)
P{5'EPgy2}Msh668
Cytology
Description

Imprecise excision of the P{EPgy2}Msh6EY07308 insertion, resulting in a deletion of Msh6 sequences. Part of the 5' end of the original insertion remains.

(Sekelsky, 2008.1.22)

Imprecise excision of a P-element insertion located 43bp upstream of the Msh6 coding sequence, resulting in a 2.8kb deletion of Msh6 coding sequence. 130bp of the P-element sequence remains.

(Radford et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Msh610/Msh668 mutants show a large increase in the incidence of postmeiotic segregation among both crossover and noncrossover products of meiotic recombination, as heteroduplex DNA (hDNA) often goes unrepaired during meiotic recombination in the mutants. hDNA amd gene conversion tracts are frequently discontinuous in the mutants, with multiple transitions between gene conversion, restoration and unrepaired hDNA.

      (Radford et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a deletion that shows loss of the 3' end of the P{EPgy2} insertion and has intact genomic sequence in the proximal direction (toward CG6876).

      (Sekelsky, 2008.1.22)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Msh668
      (Crown et al., 2014, Sekelsky, 2008.1.22, Radford et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)