FlyBase Allele Report: Dmel\levy[1]

General Information

Symbol

Dmel\levy¹

Species

D. melanogaster

Name

FlyBase ID

FBal0215556

Feature type

allele

Associated gene

Dmel\levy

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Liu et al., 2007)

Progenitor genotype

Cytology

Description

Mutation the 3' splice junction of the single levy intron.

(Liu et al., 2007)

Nucleotide substitution: G?A.

(Liu et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cytochrome-c oxidase deficiency disease

CEA

(Kemppainen et al., 2014)

model of mitochondrial encephalomyopathy

CEA

(Liu et al., 2007)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of cytochrome-c oxidase deficiency disease

is ameliorated by Zzzz\AOX^αTub84B.PK

(Kemppainen et al., 2014)

is ameliorated by Cint\AOX^αTub84B.PK

(Kemppainen et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Liu et al., 2007)

abnormal neuroanatomy (with Df(2R)levy²)

(Liu et al., 2007)

abnormal neuroanatomy (with Df(2R)levy³)

(Liu et al., 2007)

bang sensitive

(Kemppainen et al., 2014, Liu et al., 2007)

bang sensitive (with Df(2R)levy²)

(Liu et al., 2007)

bang sensitive (with Df(2R)levy³)

(Liu et al., 2007)

paralytic | heat sensitive

(Liu et al., 2007)

paralytic | heat sensitive (with Df(2R)levy²)

(Liu et al., 2007)

paralytic | heat sensitive (with Df(2R)levy³)

(Liu et al., 2007)

paralytic | heat sensitive (with Df(2R)levy⁴)

(Liu et al., 2007)

short lived

(Liu et al., 2007)

Phenotype Manifest In

adult brain

(Liu et al., 2007)

adult brain (with Df(2R)levy²)

(Liu et al., 2007)

adult brain (with Df(2R)levy³)

(Liu et al., 2007)

adult optic lobe

(Liu et al., 2007)

Detailed Description

Statement

Reference

levy¹ flies (7 days old at 29[o]C) are bang sensitive (increased recovery time).

(Kemppainen et al., 2014)

Mutant flies become paralysed on exposure to 38^o. This temperature-sensitive paralysis and recovery from it shows an age-dependent phenotype; 2 day old flies take up to 5 minutes to paralyse at 38^o and recover within 30 minutes, while 30 day old flies paralyse within 30 seconds and take up to 3 hours to recover.

Mutant flies have a reduced life span; the median life span is only 8 days at 29^o (compared to 28 days in wild-type controls) and is 51 days at 21^o (compared to 100 days in wild-type controls).

Mutant adults show age-dependent bang-induced paralysis; two day old levy¹ mutants are not paralytic in response to mechanical shock, but 73% of 10 day old flies kept at 21^o paralyse in response to a bang shock and 100% of mutant 20 day old flies are bang sensitive.

1 day old mutant adults do not show neurodegeneration, but 95% of 6 day old mutant adults do show neurodegeneration; swiss cheese-like holes appear in the brain and optic lobes. levy¹/Df(2R)levy² and levy¹/Df(2R)levy³ 6 days old adults also show neurodegeneration.

(Liu et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

levy¹ has bang sensitive phenotype, suppressible | partially by Cint\AOX^αTub84B.PK/Cint\AOX^αTub84B.PK

(Kemppainen et al., 2014)

levy¹ has bang sensitive phenotype, suppressible | partially by Scer\GAL4^da.PU/Cint\AOX^UAS.cFa

(Kemppainen et al., 2014)

NOT suppressed by

Statement

Reference

levy¹ has bang sensitive phenotype, non-suppressible by Scer\GAL4^da.PU/Scer\NDI1^UAS.cSa

(Kemppainen et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Zzzz\AOX^Scer\UAS.cFa (but not Scer\NDI1^Scer\UAS.cSa) driven by Scer\GAL4^da.PU or 4 copies of Zzzz\AOX^αTub84B.PK significantly suppresses bang sensitivity in levy¹ flies.

(Kemppainen et al., 2014)

Complementation and Rescue Data

Rescued by

levy¹ is rescued by levy^+t2

(Liu et al., 2007)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Dcp-1^k05606 complements levy¹.

(Liu et al., 2007)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

levy¹

(Kemppainen et al., 2014, Liu et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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