FB2026_02 , released June 18, 2026
Allele: Dmel\rolsEP3330
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General Information
Symbol
Dmel\rolsEP3330
Species
D. melanogaster
Name
FlyBase ID
FBal0217431
Feature type
allele
Associated gene
Dmel\rols
Associated Insertion(s)
P{EP}rolsEP3330
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Pütz et al., 2005)
Progenitor genotype
Associated Insertion(s)
P{EP}rolsEP3330
Cytology
Description

P{EP}EP3330 is inserted at 64 bp upstream of the first exon specific to rols isoform 6 (3rd exon of rols), into the putative promoter for this isoform.

(Pütz et al., 2005)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Initial determination, budding and elongation of Malpighian tubules during stage 13-14 is normal in rolsEP3330 homozygous embryos. However rearrangement of tubule cells to produce elongated, 2 cell wide tubules is delayed (from stage 15 to stage 16-17) and partially disrupted. Tubule migration is defective from stage 15. The anterior tubules appear to follow a random path through the body cavity, sometimes doubling back on themselves and failing to form the usual kink at A2/A3.

      (Pütz et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      rolsEP3330
      Name Synonyms
      Secondary FlyBase IDs
        References (1)