FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Alr1
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General Information
Symbol
Dmel\Alr1
Species
D. melanogaster
Name
FlyBase ID
FBal0221598
Feature type
allele
Associated gene
Dmel\Alr
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(McClure et al., 2008)
Progenitor genotype
P{EPgy2}EY03908
(McClure et al., 2008)
Cytology
Description

Imprecise excision of the progenitor insertion resulting in a partial deletion of Alr sequences.

(McClure et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous larvae undergo developmental arrest very early in the third larval instar and have no imaginal discs.

      Mutant first instar larval tissue cultured in vivo in wild-type adult hosts does not give rise to imaginal disc tissue.

      Heterozygous leg discs which are cut and then cultured in vivo for 48 hours form a blastema, as occurs in wild-type discs, but the blastema is significantly smaller than normal in the heterozygotes.

      (McClure et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The overgrowth phenotype that is seen in leg discs after induction of wgAct5C.PS expression in the early third larval instar is strongly suppressed if the animals are also carrying Alr1/+. A blastema is still formed at the normal time in these animals, but it is smaller than that seen in animals in which wgAct5C.PS expression has been induced in an otherwise wild-type background.

      The frequency of adults that show transdetermination (wing structures in the adult legs) after induction of wgAct5C.PS 72 hours after egg deposition is increased to 53% if the animals are also carrying Alr1/+.

      (McClure et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Alr1
      alr1
      (McClure et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)