FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Klp59DKK106365
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General Information
Symbol
Dmel\Klp59DKK106365
Species
D. melanogaster
Name
FlyBase ID
FBal0234197
Feature type
allele
Associated gene
Dmel\Klp59D
Associated Insertion(s)
Carried in Construct
P{KK106365}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK106365}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK106365
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Klp59DKK106365 under the control of Scer\GAL4ppk.PU (in combination with a Dicer-2 transgene to enhance RNAi efficiency) does not lead to any significant defects in axon or dendrite clearance after injury, or dendrite pruning 18h after the onset of pupariation, as compared to controls.

      (Tao et al., 2016)

      The spermatocyte cysts in testes of males expressing Klp59DKK106365 under the control of Scer\GAL4bam.T:Hsim\VP16 fail to elongate and severe axonemal defects (missing or broken axonemes) as well as defective ciliary cap and abnormal cilial extensions are observed in the spermatocytes.

      (Vieillard et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Klp59D KD
      (Vieillard et al., 2016)
      Klp59DKK106365
      Name Synonyms
      Secondary FlyBase IDs
        References (3)