FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sap47156
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General Information
Symbol
Dmel\Sap47156
Species
D. melanogaster
Name
FlyBase ID
FBal0241763
Feature type
allele
Associated gene
Dmel\Sap47
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Funk et al., 2004)
Progenitor genotype
P{EPgy2}Sap47EY07944
(Funk et al., 2004)
Cytology
Description

Contains a 1.7kb deletion that uncovers part of the regulatory region, the first exon and part of the first intron.

(Saumweber et al., 2011)

Imprecise excision of the progenitor insertion, resulting in a deletion of approximately 2.1kb of Sap47 sequence.

(Funk et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Sap47156 mutants exhibit normal sensory detection of odorants and tastants as well as normal motor performance and basic neurotransmission at the neuromuscular junction. However, short-term plasticity is distorted. Sap47156 show stronger depression of synaptic transmission during sustained stimulation and exhibit a significantly lower stead-state amplitude compared to controls.

      Sap47156 mutants exhibit a 50% reduction in odorant-tastant learning ability.

      Associative function is reduced to approximately 50% of wild-type levels in Sap47156 mutants. The same defect is observed for a two-odor differential conditioning paradigm.

      Sap47156 mutants do not differ from wild-type when exposed to amyl acetate or fructose.

      (Saumweber et al., 2011)

      Mutant neuromuscular junctions show reliable homeostatic compensation (increase in quantal content) after treatment with philanthotoxin-433 for 10 minutes.

      (Dickman and Davis, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Sap47156 is rescued by Scer\GAL4elav-C155/Sap47RA.UAS

      (Saumweber et al., 2011)
      Comments

      Sap47156 mutants expressing Sap47RA.Scer\UAS under the control of Scer\GAL4elav-C155 regain wild-type levels of associative function.

      (Saumweber et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Sap47156
      (Blanco-Redondo et al., 2019, Saumweber et al., 2011, Funk et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)