FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\clos1
Open Close
General Information
Symbol
Dmel\clos1
Species
D. melanogaster
Name
FlyBase ID
FBal0246095
Feature type
allele
Associated gene
Dmel\clos
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ventura et al., 2010)
Progenitor genotype
Cytology
Description

Amino acid replacement: V509D.

(Ventura et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:9,596,698..9,596,698 [-]
Nucleotide change:

T9596698A

Amino acid change:

V560D | clos-PD

Reported amino acid change:

V509D

Comment:

The site of the amino acid substitution was reported relative to an earlier version of the clos gene annotation which lacked the current 55aa starting exon and had an additional four amino acids in the next exon (previously the starting exon). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Ventura et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Females containing homozygous germline clones give rise to embryos with a terminal phenotype; anterior and posterior terminal structures do not form.

      Anterior and posterior terminal structures do not form in embryos derived from clos1/Df(2R)BSC132 females.

      87% of eggs derived from clos1/Df(2R)BSC132 females show permeability to the neutral red dye, indicating a defect in vitelline membrane integrity.

      (Ventura et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      clos1 has embryo | terminal expression pattern phenotype, suppressible by toract.RL3

      (Ventura et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The loss of anterior and posterior terminal structures seen in embryos derived from females containing homozygous clos1 germline clones is completely rescued by toract.RL3.

      (Ventura et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Df(2R)BSC132/clos1 is rescued by clos+t15.8

      (Ventura et al., 2010)
      Comments

      The loss of anterior and posterior terminal structures seen in embryos derived from clos1/Df(2R)BSC132 females is completely rescued by clos+t15.8.

      (Ventura et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      c18-9
      (Ventura et al., 2010)
      clos1
      (Ventura et al., 2010)
      Name Synonyms
      closca-1
      (Ventura et al., 2010)
      Secondary FlyBase IDs
        References (1)