FlyBase Allele Report: Dmel\Mtpβ[HMS01017]

General Information

Symbol

Dmel\Mtpβ^HMS01017

Species

D. melanogaster

Name

FlyBase ID

FBal0257684

Feature type

allele

Associated gene

Dmel\Mtpβ

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01017}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01017}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01017

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of mitochondrial trifunctional protein deficiency

CEC

(Li et al., 2019)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

FlyBase curator comment: "mitochondrial trifunctional protein deficiency" is associated with human ortholog HADHB.

(Li et al., 2019)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning | larval stage, with Scer\GAL4^elav.PLu

(Li et al., 2019)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^elav.PLu

(Li et al., 2019)

abnormal locomotor behavior | larval stage, with Scer\GAL4^elav.PLu

(Li et al., 2019)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav.PLu

(Li et al., 2019)

decreased size | third instar larval stage, with Scer\GAL4^elav.PLu

(Li et al., 2019)

male fertile, with Scer\GAL4^bam.PU

(François et al., 2023)

short lived, with Scer\GAL4^elav.PLu

(Li et al., 2019)

visible | adult stage, with Scer\GAL4^GMR.PU

(Shimada et al., 2020)

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^elav.PLu

(Li et al., 2019)

eye, with Scer\GAL4^GMR.PU

(Shimada et al., 2020)

muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage, with Scer\GAL4^elav.PLu

(Li et al., 2019)

type I bouton | third instar larval stage, with Scer\GAL4^elav.PLu

(Li et al., 2019)

Detailed Description

Statement

Reference

The expression of Mtpβ^HMS01017 under the control of Scer\GAL4^GMR.PU induces a rough eye phenotype.

(Shimada et al., 2020)

The expression of Mtpβ^HMS01017 under the control of Scer\GAL4^elav.PLu induces locomotor defects in larvae (decreased crawling speed) and adults (progressive decrease in climbing activity); third instar larvae exhibit abnormal synapse morphology at NMJ in muscle 4 of (shorter NMJ and decreased number of type Ib boutons); larvae also show learning defects in olfactory learning assays.

(Li et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Mtpβ^HMS01017, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by asRNA:CR43467^GD604, Scer\GAL4^GMR.PU

(Shimada et al., 2020)

Mtpβ^HMS01017, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible | partially by asRNA:CR43467^HMJ22886, Scer\GAL4^GMR.PU