FlyBase Allele Report: Dmel\hppy[SH1261]

General Information

Symbol

Dmel\hppy^SH1261

Species

D. melanogaster

Name

FlyBase ID

FBal0261150

Feature type

allele

Associated gene

Dmel\hppy

Associated Insertion(s)

P{lacW}hppy^SH1261

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Oh et al., 2003)

Progenitor genotype

Associated Insertion(s)

P{lacW}hppy^SH1261

Cytology

Description

Insertion in the second intron.

(Bryk et al., 2010)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:19,181,893..19,181,893 [+]

(Bryk et al., 2010, FlyBase Curators, 2008-, Oh et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | larval stage

(Bryk et al., 2010)

abnormal size | adult stage

(Bryk et al., 2010)

decreased cell size | adult stage

(Bryk et al., 2010)

fertile

(Bryk et al., 2010)

lethal | recessive

(Oh et al., 2003)

short lived

(Bryk et al., 2010)

visible

(Bryk et al., 2010)

Phenotype Manifest In

wing

(Bryk et al., 2010)

Detailed Description

Statement

Reference

Homozygotes show reduced viability, with 18% of adults dying within 2 days of eclosion.

Homozygotes are delayed in pupation relative to controls by almost 2 days under standard food conditions. They display a slower growth rate during larval stages. The mutant larvae show a larger inter-individual variation in growth rate compared to controls.

Under low amino-acid nutrient conditions homozygous animals grow at the same rate as controls (both show slower growth rates than under standard food conditions).

Homozygous adults have smaller wings compared to wild type. The wing cells are significantly reduced in size compared to controls.

Homozygous and hppy^SH1261/Df(2R)Exel6069 adults show a reduction in total body triglyceride levels.

(Bryk et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The overgrowth of the posterior compartment of the wing which is caused by expression of RagA^{Q61L.Scer\UAS} under the control of Scer\GAL4^en.PU is still seen in a hppy^SH1261 background.

(Bryk et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

hppy^SH1261 is rescued by hppy^UAS.cTa/Scer\GAL4^da.G32

(Bryk et al., 2010)

Comments

Expression of hppy^Scer\UAS.cTa under the control of Scer\GAL4^da.G32 rescues the reduced total body triglyceride levels of hppy^SH1261 homozygotes.

(Bryk et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

29493

w^*; P{FRT(w^hs)}G13 P{lacW}hppy^SH1261/CyO

Notes on Origin

Discoverer

The lethality of the original insertion chromosome may or may not be caused by this allele.

(FlyBase Curators, 2008-)

Comments

Precise excision of the insertion reverts the mutant phenotype.

(Bryk et al., 2010)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

hppy^SH1261

(Datta et al., 2023)

l(2)SH1261

(Bryk et al., 2010)

l(2)SH1261^SH1261

Name Synonyms

Secondary FlyBase IDs

FBal0242901
FBal0143723

References (4)

Report Sections

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