FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\MYBPC3M0.UAS.Tag:MYC
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General Information
Symbol
Hsap\MYBPC3M0.UAS.Tag:MYC
Species
H. sapiens
Name
FlyBase ID
FBal0269974
Feature type
allele
Associated gene
Hsap\MYBPC3
Associated Insertion(s)
Carried in Construct
P{UAS-MYBPC3.M0}
Key Links
Transgenic product class
inframe_deletion
(Manh et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Manh et al., 2005)
Mutagen
in vitro construct
(Manh et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-MYBPC3.M0}
Cytology
Description

UASt regulatory sequences drive expression of a C-terminally truncated form of Hsap\MYBPC3 (lacks the C5-C10 domains) which is tagged with Tag:MYC.

(Manh et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\MYBPC3
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  myopathy
      CEA
      (Manh et al., 2005)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  myopathy
      is ameliorated by Cam03909
      (Manh et al., 2005)
      is ameliorated by Camk04213
      (Manh et al., 2005)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Manh et al., 2005)

      This construct encodes a truncated protein comparable to the MYBPC3 c.1928-2A>G variant, which occurs in a canonical splice acceptor site, resulting in exon skipping and premature termination.

      MYBPC3:p.Gln642Ter
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      MYBPC3:c.1928-2A>G
      Associated human disease model(s)
      External database links
      ClinVar: MYBPC3_42585
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Hsap\MYBPC3M0.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4sd-SG29.1 are flightless and hold their wings in abnormal position compared to wild type. The severity of the phenotype is age- and dose-dependent. 15 day old flies carrying two copies of Hsap\MYBPC3M0.Scer\UAS.T:Hsap\MYC show distortion of the Z-band in indirect flight muscles. Deformation of the M-line is occasionally seen and the I-band appears stretched and disorganised. The sarcomeres are approximately 10% shorter on average than in control flies.

      (Manh et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Heterozygosity for either Camk04213 or Cam03909 partially rescues the flightless phenotype caused by expression of Hsap\MYBPC3M0.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4sd-SG29.1.

      (Manh et al., 2005)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\MYBPC3M0.Scer\UAS.T:Hsap\MYC
      Hsap\MYBPC3M0.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)