FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\IdeKO
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General Information
Symbol
Dmel\IdeKO
Species
D. melanogaster
Name
FlyBase ID
FBal0280986
Feature type
allele
Associated gene
Dmel\Ide
Associated Insertion(s)
TI{TI}IdeKO
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-out gene targeting
(Tsuda et al., 2010)
FLPase
(Tsuda et al., 2010)
I-SceI
(Tsuda et al., 2010)
Progenitor genotype
Associated Insertion(s)
TI{TI}IdeKO
Cytology
Description

Exons 9 and 10 of the Ide locus (which includes the region encoding for the substrate binding region) have been deleted and replaced by a w+* marker.

(Tsuda et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:20,373,121..20,373,570 [-]
Comment:

Deletion in Ide generated by ends-out homologous recombination.

(Tsuda et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      IdeKO mutants show a significant reduction in pupal volume in comparison to controls.

      The 3-day delay in pupariation onset seen in wild type larvae raised in high-sucrose medium is prolonged by >1 day in IdeKO mutants. (Under regular feeding conditions, the mutant and wild type develop at almost the same rate.)

      Whereas circulating levels of trehalose drop sharply after 24 hr starvation in wild type adult flies, levels remain close to those observed before starvation in IdeKO flies.

      (Galagovsky et al., 2014)

      Flies homozygous for IdeKO are found to be viable and fertile with no obvious developmental defects. No significant difference is observed in mean body weight between IdeKO and wild-type controls. IdeKO homozygotes and wild-type controls show no significant difference in glucose concentration in the hemolymph. However, IdeKO mutant flies display 86% higher trehalose concentration in their hemolymph than do wild-type controls.

      IdeKO mutant flies live longer than wild-type.

      (Tsuda et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      IdeKO
      (Galagovsky et al., 2014)
      dIdeKO
      (Tsuda et al., 2010)
      dldeKO
      (Tsuda et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)