FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eyaWT.UAS.NLS-MUT
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General Information
Symbol
Dmel\eyaWT.UAS.NLS-MUT
Species
D. melanogaster
Name
FlyBase ID
FBal0287993
Feature type
allele
Associated gene
Dmel\eya
Associated Insertion(s)
Carried in Construct
P{UAS-eya.WT.NLS-MUT}
Key Links
Transgenic product class
wild_type
(Xiong et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Xiong et al., 2009)
Mutagen
in vitro construct
(Xiong et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-eya.WT.NLS-MUT}
Cytology
Description

UAS regulates expression of wild type eya fused to a non-functional mutant nuclear localization sequence (Tag:NLS(SV40-largeT) mutated from PPKKKRKV to PPKAARKV).

(Xiong et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
eya
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4dpp.blk1 eyaWT.Scer\UAS.T:SV40\nls2-MUT flies exhibit an average of ~35% frequency of ectopic eye induction (compared to 49% frequency when eyaWT.Scer\UAS is expressed).

      (Xiong et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      eyaWT.UAS.NLS-MUT/Scer\GAL4dpp.blk1 rescues eya2

      (Xiong et al., 2009)
      Comments

      Scer\GAL4dpp.blk1-mediated expression of eyaWT.Scer\UAS.T:SV40\nls2-MUT fully rescues the eyeless phenotype of eya2 animals.

      (Xiong et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      eyaWT.Scer\UAS.T:SV40\nls-largeT-MUT
      eyaWT.Scer\UAS.T:SV40\nls2-MUT
      eyaWT.UAS.NLS-MUT
      eyaWT.UAS.T:SV40\nls-largeT-MUT
      Name Synonyms
      Secondary FlyBase IDs
        References (2)