FlyBase Allele Report: Hsap\FBXO7[UAS.1]

General Information

Symbol

Hsap\FBXO7^UAS.1

Species

H. sapiens

Name

FlyBase ID

FBal0290427

Feature type

allele

Associated gene

Hsap\FBXO7

Associated Insertion(s)

Carried in Construct

M{UAS-FBXO7.1}

Key Links

Transgenic product class

wild_type

(Burchell et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Burchell et al., 2013)

Mutagen

in vitro construct

(Burchell et al., 2013)

Progenitor genotype

Carried in construct

M{UAS-FBXO7.1}

Cytology

Description

UASt regulatory sequences drive expression of the entire open reading frame of isoform 1 of Hsap\FBXO7.

(Burchell et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\FBXO7

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by park²⁵

(Burchell et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^Ddc.PU

(Zhou et al., 2015)

abnormal neuroanatomy | adult stage, with Scer\GAL4^Ddc.PU

(Zhou et al., 2015)

Phenotype Manifest In

dopaminergic PPM1 neuron, with Scer\GAL4^Ddc.PU

(Zhou et al., 2015)

dopaminergic PPM2 neuron, with Scer\GAL4^Ddc.PU

(Zhou et al., 2015)

dopaminergic PPM3 neuron, with Scer\GAL4^Ddc.PU

(Zhou et al., 2015)

mitochondrion | adult stage, with Scer\GAL4^how-24B

(Zhou et al., 2015)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\FBXO7^UAS.1/Scer\GAL4^da.G32 is a suppressor of abnormal locomotor behavior phenotype of park²⁵

(Burchell et al., 2013)

Hsap\FBXO7^UAS.1/Scer\GAL4^da.G32 is a suppressor of abnormal neuroanatomy phenotype of park²⁵

(Burchell et al., 2013)

Hsap\FBXO7^UAS.1/Scer\GAL4^da.G32 is a suppressor of abnormal flight phenotype of park²⁵

(Burchell et al., 2013)

NOT Suppressor of

Statement

Reference

Hsap\FBXO7^UAS.1/Scer\GAL4^da.G32 is a non-suppressor of abnormal flight phenotype of Pink1^B9

(Burchell et al., 2013)

Hsap\FBXO7^UAS.1/Scer\GAL4^da.G32 is a non-suppressor of abnormal locomotor behavior phenotype of Pink1^B9

(Burchell et al., 2013)

Hsap\FBXO7^UAS.1/Scer\GAL4^da.G32 is a non-suppressor of abnormal neuroanatomy phenotype of Pink1^B9

(Burchell et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\FBXO7^UAS.1/Scer\GAL4^da.G32 is a suppressor of dopaminergic neuron phenotype of park²⁵

(Burchell et al., 2013)

Hsap\FBXO7^UAS.1/Scer\GAL4^da.G32 is a suppressor of mitochondrion phenotype of park²⁵

(Burchell et al., 2013)

Hsap\FBXO7^UAS.1/Scer\GAL4^da.G32 is a suppressor of adult somatic muscle cell phenotype of park²⁵

(Burchell et al., 2013)

NOT Suppressor of

Statement

Reference

Hsap\FBXO7^UAS.1/Scer\GAL4^da.G32 is a non-suppressor of neuron phenotype of Pink1^B9

(Burchell et al., 2013)

Hsap\FBXO7^UAS.1/Scer\GAL4^da.G32 is a non-suppressor of mitochondrion phenotype of Pink1^B9

(Burchell et al., 2013)

Hsap\FBXO7^UAS.1/Scer\GAL4^da.G32 is a non-suppressor of adult somatic muscle cell phenotype of Pink1^B9

(Burchell et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Scer\GAL4^da.G32>Hsap\FBXO7^Scer\UAS.cBb is not able to rescue the Pink1^B9 locomotor deficits, neuron loss, muscle degeneration or mitochondrial disruption.

Expression of Scer\GAL4^da.G32>Hsap\FBXO7^Scer\UAS.cBb significantly suppresses the park²⁵ phenotypes, including locomotor defects, dopaminergic neuron loss, muscle degeneration, and mitochondrial disruption.

(Burchell et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

99022

w^*; M{UAS-FBXO7.1}ZH-51C

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Hsap\FBXO7^Scer\UAS.cBb

Hsap\FBXO7^UAS.1

Hsap\FBXO7^UAS.cBb

Name Synonyms

Saccharomyces cerevisiae UAS construct b of Burchell

Secondary FlyBase IDs

References (2)

Report Sections

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