FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sunnZ3-5839
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General Information
Symbol
Dmel\sunnZ3-5839
Species
D. melanogaster
Name
FlyBase ID
FBal0303706
Feature type
allele
Associated gene
Dmel\sunn
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Krishnan et al., 2014)
Progenitor genotype
Cytology
Description

Deletion of 8 nucleotides, 1894-1901bp, creating a frameshift that introduces a premature STOP codon in the 6th exon (near the middle of the coding sequence).

(Krishnan et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:11,730,311..11,730,318 [+]
Comment:

8bp deletion of nucleotides 1894-1901 (from the ATG) that leads to a frameshift and early translation termination in the 6th exon.

(Krishnan et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The progeny of sunnZ3-5839 homozygous males mated to normal females show increased sex chromosome non-disjunction.

      The progeny of sunnZ3-5839/Df(3L)ED4470 show increased homologous and sister chromatid non-disjunction in both male and female meiosis. This is true of the sex chromosomes, and the autosomal second and fourth chromosomes.

      sunnZ3-5839/Df(3L)ED4470 spermatocytes appear normal in male meiosis I. However, prematurely separated sister chromatids are common during and after anaphase I, and meiosis II is chaotic. Mutants begin losing centromere cohesion by stage S4 and exhibit extensive cohesion loss by stage S5. This results in disrupted sister centromere mono-orientation. Arm cohesion in early meiotic prophase I, and mitotic segregation is normal in these mutants.

      Oocytes from sunnZ3-5839/Df(3L)ED4470 females show disruption of centromere clustering, pairing and cohesion during meiosis.

      (Krishnan et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Df(3L)ED4470/sunnZ3-5839 is rescued by sunnUASp.Venus/Scer\GAL4VP16.nanos.UTR

      (Krishnan et al., 2014)
      Comments

      Scer\GAL4nos.UTR.T:Hsim\VP16-mediated expression of sunnScer\UAS.P\T.T:Avic\GFP-YFP.Venus rescues the meiotic non-disjunction phenotype of sunnZ3-5839/Df(3L)ED4470 mutants in both sexes.

      (Krishnan et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      From the Zuker-3 collection.

      (Krishnan et al., 2014)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sunnZ3-5839
      (Krishnan et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)