FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eater1
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General Information
Symbol
Dmel\eater1
Species
D. melanogaster
Name
FlyBase ID
FBal0304323
Feature type
allele
Associated gene
Dmel\eater
Associated Insertion(s)
TI{TI}eater1
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Bretscher et al., 2015)
Mutagen
ends-out gene targeting
(Bretscher et al., 2015)
I-SceI
(Bretscher et al., 2015)
FLPase
(Bretscher et al., 2015)
Progenitor genotype
Associated Insertion(s)
TI{TI}eater1
Cytology
Description

745 bp deletion removing the ATG translation start site, the first and second exons, and 18 bp of the third exon. A 7.9kb cassette carrying a w+* marker replaces the deleted sequence.

(Bretscher et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:27,098,917..27,099,663 [-]
Comment:

745 bp region at the 5' end of eater (which includes the ATG translation start site, the first and second exons, and 18 bp of the third exon) was deleted by homologous recombination and replaced with a 7.9kb cassette carrying the w gene.

(Bretscher et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      eater1 homozygotes raised on poor diet exhibit partial lethality during P-stage.

      (Ramond et al., 2020)

      Flies carrying the eater1 lesion are viable and appear developmentally wild type.

      eater1 larval hemocytes show defects in phagocytosis of Gram-positive but not Gram-negative bacteria.

      Sessile plasmatocytes are absent or almost absent in eater1 mutant larvae. Dissected eater1 mutant larvae release more than three times the number of hemocytes than wild-type, indicating an abnormally high number of hemocytes in circulation. The lymph glands of eater1 mutant larvae are not visibly different in size to those of wild-type. The sessile plasmatocyte striped pattern evident in wild-type larvae is absent in eater1 mutants. All or almost all plasmatocytes in the mutant larvae are in circulation and appear not to enter the sessile state. This 'no sessile plasmatocyte' phenotype is phenocopied in trans-heterozygous larvae carrying eater1 over the deficiencies Df(3R)Exel6206 and Df(3R)BSC791.

      Clonal analysis of eater1 mutant hemocytes indicates that the sessile plasmatocyte defect is a cell-autonomous phenotype.

      Compared with wild-type, eater1 mutant plasmatocytes show a reduction in cell area on a glass substrate, indicating defects in adhesion.

      Sessile crystal cells are absent or almost absent in eater1 mutant larvae.

      (Bretscher et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      eater1, NimC11 larval macrophages show decreased phagocytosis of apoptotic cells and S. aureus bacteria.

      (Petrignani et al., 2021)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      References (9)