FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dahbnk.A
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General Information
Symbol
Dmel\dahbnk.A
Species
D. melanogaster
Name
FlyBase ID
FBal0318131
Feature type
allele
Associated gene
Dmel\dah
Associated Insertion(s)
Carried in Construct
M{UDMEL-Myd88T-dahA}
PBac{UDMEL-Myd88T-dahA}
Key Links
Transgenic product class
wild_type
(Akbari et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Akbari et al., 2013)
Mutagen
in vitro construct
(Akbari et al., 2013)
Progenitor genotype
Carried in construct
M{UDMEL-Myd88T-dahA}
PBac{UDMEL-Myd88T-dahA}
Cytology
Description

A transient early-zygotic promoter (bnk) drives expression of dah lacking the 5' UTR, which prevents it from being silenced by one of the sequences targeted by dahmiRNA.bcd.T. To prevent it being silenced by the second miRNA in dahmiRNA.bcd.T, which targets an exon, the nucleotide sequence has been recoded such that it codes for the same amino acid sequence but is not targeted by the miRNA. This allele is used as an 'antidote' in the maternal-effect-lethal underdominance (UD[MEL]) system.

(Akbari et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
bnk
Encoded product / tool
dah
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      This allele is used as part of the maternal-effect-lethal underdominance (UD[MEL]) system. The U[DMEL] system utilizes two constructs, each consisting of a maternally expressed toxin and a zygotically expressed antidote. Each antidote is linked with a toxin whose activity it does not rescue (toxin A linked with antidote B and vice versa). As a result, the survival of embryos from mothers carrying one (UD[MEL-1]) or both (UD[MEL-1] and UD[MEL-2]) kinds of UD[MEL] chromosomes requires that they inherit the other (UD[MEL-2]) or both kinds of UD[MEL] chromosomes, respectively, in order to achieve zygotic rescue.

      (Akbari et al., 2013)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dahbnk.A
      Name Synonyms
      Secondary FlyBase IDs
        References (1)