FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Ras85DV12.QUAS
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General Information
Symbol
Dmel\Ras85DV12.QUAS
Species
D. melanogaster
Name
FlyBase ID
FBal0318840
Feature type
allele
Associated gene
Dmel\Ras85D
Associated Insertion(s)
Carried in Construct
M{QUAS-Ras85D.V12}
P{QUAS-Ras85D.V12}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Gallant, 2016.4.27)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Gallant, 2016.4.27)
Mutagen
in vitro construct
(Gallant, 2016.4.27)
Progenitor genotype
Carried in construct
M{QUAS-Ras85D.V12}
P{QUAS-Ras85D.V12}
Cytology
Description

QUAS regulatory sequences drive expression of a constitutively active form of Ras85D.

(Gallant, 2016.4.27)
Allele components
Component
Use(s)
Regulatory region(s)
QUAS
Encoded product / tool
Ras85D
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:9,512,257..9,512,257 [-]
Nucleotide change:

G9512257T

Amino acid change:

G12V | Ras85D-PA

Comment:

Analogous to oncogenic mutations in one of three human RAS genes; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(FlyBase curators, 2019-)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (FlyBase curators, 2019-)

      This somatic variant has been found associated with cancer in each of the three paralogous genes in human (KRAS, HRAS, NRAS).

      HRAS:p.Gly12Val
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      ClinVar: 12600
      Comments concerning this variant
      KRAS:p.Gly12Val
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      ClinVar: 12583
      Comments concerning this variant
      NRAS:p.Gly12Val
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      ClinVar: 40470
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ras85DV12.Ncra\QUAS
      Ras85DV12.QUAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)