FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\WwoxP277A.UAS
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General Information
Symbol
Dmel\WwoxP277A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0369218
Feature type
allele
Associated gene
Dmel\Wwox
Associated Insertion(s)
Carried in Construct
M{UAS-Wwox.P277A}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Choo et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Choo et al., 2015)
Mutagen
in vitro construct
(Choo et al., 2015)
Progenitor genotype
Carried in construct
M{UAS-Wwox.P277A}
Cytology
Description

UAS regulatory sequences drive expression of the Wwox open reading frame, mutated to carry a P277A amino acid substitution. This change is equivalent to a P282A change in the orthologous human WWOX gene, a variant associated with an increased risk of thyroid cancer.

(Choo et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Wwox
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:8,000,387..8,000,387 [-]
Nucleotide change:

C8000387G

Reported nucleotide change:

C?G

Amino acid change:

P277A | Wwox-PA; P277A | Wwox-PB

Reported amino acid change:

P277A

Comment:

Analogous P282A mutation in human WWOX implicated in increased risk of thyroid cancer; mutation carried on in vitro construct.

(Choo et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Choo et al., 2015)
      WWOX:p.Pro282Ala
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      WWOX:p.Pro169Ala
      Associated human disease model(s)
      External database links
      ClinVar: 260745
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      WwoxP277A.UAS, Scer\GAL4ey.PU is a suppressor | partially of eye phenotype of ND-23GD11167, Scer\GAL4ey.PU

      (Choo et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      WwoxP277A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)