FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nup358::RanGAPA.ΔRA
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General Information
Symbol
Dmel\Nup358::RanGAPA.ΔRA
Species
D. melanogaster
Name
FlyBase ID
FBal0371384
Feature type
allele
Associated gene
Nup358::RanGAP
Associated Insertion(s)
Carried in Construct
P{Nup358A::RanGAPΔRA}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Chen et al., 2021)
Progenitor genotype
Carried in construct
P{Nup358A::RanGAPΔRA}
Cytology
Description

Nup358 regulatory sequences drive expression of a fusion protein that is composed of the coding sequence for the Nup358 A isoform (a 69bp sequence that is only present in the B isoform has been deleted from the coding sequence) fused to a portion of RanGAP with a truncation of the C-terminal regulatory domain. In addition, the RanGAP coding sequence has been mutated to carry a R87A amino acid substitution, resulting in it being catalytically inactive.

(Chen et al., 2021)
Allele components
Component
Use(s)
Regulatory region(s)
Nup358
Encoded product / tool
Nup358::RanGAP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      Nup358::RanGAPA.ΔRA is a non-suppressor of abnormal developmental rate | recessive | P-stage phenotype of Nup358A

      (Chen et al., 2021)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Nup358::RanGAPA.ΔRA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)