FB2026_03 , released September 17, 2026
Chemical: sitagliptin
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General Information
Name
sitagliptin
FlyBase ID
FBch0003175
ChEBI Name
sitagliptin
ChEBI ID
CHEBI:40237
PubChem Name
Sitagliptin
PubChem ID
CID:4369359
Chemical Structure
Chemical structure of sitagliptin
sitagliptin
InChIKey

MFFMDFFZMYYVKS-SECBINFHSA-N

Definition (ChEBI)

A triazolopyrazine that exhibits hypoglycemic activity. ChEBI: Sitagliptin is a triazolopyrazine that exhibits hypoglycemic activity. It has a role as a serine proteinase inhibitor, a hypoglycemic agent, an EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor, an environmental contaminant and a xenobiotic. It is a triazolopyrazine and a trifluorobenzene.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (15)
Synonyms
(2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE
(ChEBI, 2019-)
(3R)-3-AMINO-1-[3-(TRIFLUOROMETHYL)-5H,6H,7H,8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7-YL]-4-(2,4,5-TRIFLUOROPHENYL)BUTAN-1-ONE
(PubChem, 2019-)
(3R)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
(ChEBI, 2019-)
486460-32-6
(PubChem, 2019-)
Januvia
(PubChem, 2019-)
LEZ763
(PubChem, 2019-)
MK-0431
(ChEBI, 2019-)
PubChem:4369359
(PubChem, 2019-)
QFP0P1DV7Z
(PubChem, 2019-)
Sitagliptin
(PubChem, 2019-)
Zituvio
(PubChem, 2019-)
sitagliptin
(Yizibula et al., 2026, Brunetti et al., 2025, ChEBI, 2019-, PubChem, 2019-)
sitagliptina
(ChEBI, 2019-, PubChem, 2019-)
sitagliptine
(ChEBI, 2019-, PubChem, 2019-)
sitagliptinum
(ChEBI, 2019-, PubChem, 2019-)
Secondary FlyBase IDs
    References (4)