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General Information
Name
MITOCHONDRIAL COMPLEX I - CORE SUBUNITS
Species
D. melanogaster
Symbol
MCI-C
FlyBase ID
FBgg0001386
Date last reviewed
2021-02-23
Number of members
19
Description
Description
Mitochondrial Complex I is the first and largest holoenzyme of the mitochondrial electron transport chain. It oxidizes NADH from the tricarboxylic acid cycle and β oxidation of fatty acids, reduces ubiquinone and transports protons across the inner membrane, contributing to the proton-motive force. It is also involved in the cellular production of reactive oxygen species. Fourteen distinct subunits form the catalytic centers of the enzyme as they are directly involved in transferring electrons from NADH to ubiquinone, or for generation of the membrane potential - they are referred to as the 'core' or 'central' subunits and are conserved from the ancestral enzyme in bacteria to mammals. Seven core subunits are encoded by mtDNA, while the others are encoded the nuclear genome. (Adapted from PMID:23527692 and FBrf0244962.)
Notes on Group

The division between 'CORE' and 'ACCESSORY' Complex I subunits in FlyBase follows that given in FBrf0244962.

Several nuclear genes encoding core subunits of Complex I exist as paralogs in D. melanogaster: ND-49 and ND-49L; ND-20 and ND-20L; ND-51, ND-51L1 and ND-51L2; ND-24 and ND-24L.

Source Material
The MITOCHONDRIAL COMPLEX I - CORE SUBUNITS Gene Group has been compiled by FlyBase curators using the following publication(s): Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, Tripoli et al., 2005, and Fearnley and Walker, 1992 .
Key Gene Ontology (GO) terms
Enzymatic activity
Enzyme name (EC)
NADH:ubiquinone reductase (H(+)-translocating) (7.1.1.2)
Related Gene Groups
Members (19)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
mitochondrial NADH-ubiquinone oxidoreductase chain 1
ND1, dND1, ND-1, nad1
mitochondrial NADH-ubiquinone oxidoreductase chain 2
ND2, dND2, NADH dehydrogenase subunit 2, nad2
mitochondrial NADH-ubiquinone oxidoreductase chain 3
ND3, dND3
mitochondrial NADH-ubiquinone oxidoreductase chain 4
ND4, BEST:CK00534, nad4, dND4
mitochondrial NADH-ubiquinone oxidoreductase chain 4L
ND4L, dND4L
mitochondrial NADH-ubiquinone oxidoreductase chain 5
ND5, dND5, nad5
mitochondrial NADH-ubiquinone oxidoreductase chain 6
ND6, nad6, dND6
NADH dehydrogenase (ubiquinone) 20 kDa subunit-like
NADH: ubiquinone oxidoreductase-like, 20kDa subunit, ND20-like
NADH dehydrogenase (ubiquinone) 23 kDa subunit
ND23, NADH:ubiquinone reductase 23kD subunit precursor, dNDUFS8
NADH dehydrogenase (ubiquinone) 51 kDa subunit
ND51, dNDUFV1, NADH dehydrogenase, NADH:ubiquinone oxidoreductase, 51kDa subunit
NADH dehydrogenase (ubiquinone) 75 kDa subunit
ND75, NADH:ubiquinone reductase 75kD subunit precursor, NDUFS1
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
MCI-C
MITOCHONDRIAL COMPLEX I - CORE SUBUNITS
Secondary FlyBase ID(s)
References (8)