FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Pathway: L-GLUTAMATE BIOSYNTHESIS (FROM L-PROLINE)
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General Information
Name
L-GLUTAMATE BIOSYNTHESIS (FROM L-PROLINE)
Species
D. melanogaster
Symbol
LGLUBIP
FlyBase ID
FBgg0002187
Date last reviewed
2025-01-27
Number of members
2
Description
Description
L-glutamate is a non-essential amino acid and can be synthesized in the mitochondrion from L-proline. Besides its role in protein synthesis, L-glutamate is required for the production of GABA, L-serine, L-proline, L-alanine, glutathione and is part of the malate-aspartate shuttle. In addition, L-glutamate acts as a neurotransmitter and is used for the glutamylation of tubulin and the tetrahydrofolate cofactor. (Adapted from PMID:34291343.)
Notes

P5CDh2 is a paralog of P5CDh1 and is specifically expressed in testis. As there is no functional information, P5CDh2 is not included in the gene list.

Source Material
The L-GLUTAMATE BIOSYNTHESIS (FROM L-PROLINE) Gene Group has been compiled using the following publication(s): He and DiMario, 2011 and Hayward et al., 1993 .
Key Gene Ontology (GO) terms
Biological Process
L-glutamate biosynthetic process
L-proline catabolic process
Cellular Component
mitochondrion
Related Gene Groups
Parent group(s)
AMINO ACID METABOLISM
GO Causal Activity Model (GO-CAM)
Members (2)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)
Note: The Drosophila pathways shown at these resources are computed using different methods. They may therefore differ from the manually curated and verified pathway shown above.

[FlyCyc: L-proline degradation I)](https://biocyc.org/pathway?orgid=DMEL&id=PROUT-PWY)

[Reactome: Proline catabolism](https://reactome.org/PathwayBrowser/#/R-DME-70688)

[KEGG: Arginine and proline metabolism](https://www.kegg.jp/kegg-bin/show_pathway?dme00330)

Synonyms and Secondary IDs
Synonym(s)
LGLUBIP
L-proline catabolism to L-glutamate
L-GLUTAMATE BIOSYNTHESIS (FROM L-PROLINE)
Secondary FlyBase ID(s)
References (3)