FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Human Disease Model Report: intellectual disability, X-linked, syndromic
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General Information
Name
intellectual disability, X-linked, syndromic
FlyBase ID
FBhh0000125
Disease Ontology Term
Parent Disease
OMIM
Overview

This report describes general characteristics of the group of diseases classified as intellectual disability, X-linked, syndromic, also described as mental retardation, X-linked syndromic. This is a genetically heterogeneous set of disorders with many causative genes and mapped loci; the prefix 'MRX' is frequently used in naming X-linked implicated genes for both syndromic and nonsyndromic forms. A comprehensive list of X-linked syndromic subtypes, as defined by OMIM (which number 50 to date), may be found by following the link in the "OMIM phenotypic series" section, below. A subset of these may be found in the table below, with links to more detailed reports for subtypes that have been investigated using fly models.

[updated Mar. 2020 by FlyBase; FBrf0222196]

Disease Summary Information
Parent Disease Summary: intellectual disability, X-linked, syndromic
OMIM report
Symptoms and phenotype

Intellectual disability is characterized by impairments in intellectual functioning and adaptive behavior; symptoms must be present before a child becomes 18 years old (http://medical-dictionary.thefreedictionary.com/mental+retardation; 2016.01.19).

(FlyBase Curators, 2013-)

Intellectual disability can be subdivided into syndromic forms, characterized by cognitive impairment accompanied by dysmorphic features, malformations or neurological abnormalities, and nonsyndromic forms, characterized by cognitive impairment without additional features (Basel-Vanagaite, 2008; DOI: 10.1002/9780470015902.a0021454).

(FlyBase Curators, 2013-)
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    intellectual disability, X-linked syndromic
    mental retardation, X-linked syndromic
    syndromic X-linked intellectual disability
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (2)